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Donor organ cardioplegia solution: Drug information

Donor organ cardioplegia solution: Drug information
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For additional information see "Donor organ cardioplegia solution: Pediatric drug information"

For abbreviations, symbols, and age group definitions show table
Brand Names: US
  • Custodiol HTK
Brand Names: Canada
  • Custodiol HTK
Pharmacologic Category
  • Cardioplegia Solution
Adverse Reactions

There are no adverse reactions listed in the manufacturer's labeling.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution for Perfusion:

Custodiol HTK: (500 mL, 1000 mL, 2000 mL, 5000 mL)

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution for Perfusion:

Custodiol HTK: (1000 mL, 2000 mL, 5000 mL)

Administration: Adult

Solution is not for continuous perfusion; leave solution in the organ vasculature during hypothermic storage and transportation. Perfuse with a maximum hydrostatic pressure of 120 mm Hg. Not for IV or intra-arterial administration.

Administration: Pediatric

Solution is not for continuous perfusion; leave solution in the organ vasculature during hypothermic storage and transportation. Perfuse with a maximum hydrostatic pressure of 120 mm Hg. Not for IV or intra-arterial administration.

Use: Labeled Indications

Donor organ perfusion: Flushing and perfusion of donor heart, kidneys, liver, and pancreas prior to or immediately after removal from the donor.

Medication Safety Issues
High alert medication:

The Institute for Safe Medication Practices (ISMP) includes this medication among its list of drug classes (cardioplegic solution) which have a heightened risk of causing significant patient harm when used in error (High-Alert Medications in Acute Care Settings).

International issues:

Custodiol [US, Canada, and multiple international markets] is also the brand name for bisacodyl [Indonesia].

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

  1. Custodiol HTK Solution (histidine, tryptophan, and ketoglutarate cardioplegia solution) [prescribing information]. Ewing, NJ: Essential Pharmaceuticals LLC; October 2020.
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