VIM DBS | STN or GPi DBS | LCIG | CSAI | Conventional pallidotomy | FUS thalamotomy | FUS pallidotomy | |
Indications | Refractory PD tremor | Motor fluctuations or refractory PD tremor | Motor fluctuations | Motor fluctuations | Motor fluctuations | Refractory PD tremor | Motor fluctuations |
Can be performed bilaterally? | No | Yes | N/A | N/A | No | No | No |
Surgery required? | Yes, scalp incision/burr hole | Yes, scalp incision/burr hole | Yes, PEG-J placement | No | Yes | No | No |
Intentional brain lesion? | No | No | No | No | Yes | Yes | Yes |
Reversible? | Yes | Yes | Yes | Yes | No | No | No |
Randomized, placebo, or sham-controlled trial data available? | No | Yes | Yes | Yes | Randomized trial with blinded evaluators | Yes | Yes |
Long-term data (>2 years) available? | Yes | Yes | Yes | Yes | Yes | No | No |
Clinical availability | Full | Full | Full | Not approved for use in United States | Full | Limited number of centers | Limited number of centers |
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