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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Serum steroid concentrations in reference population of females, including girls with premature adrenarche: Median with interquartile range[1,2]

Serum steroid concentrations in reference population of females, including girls with premature adrenarche: Median with interquartile range[1,2]
Steroid Ages 4 to 5 years
(n = 22)
Ages 6 to 8 years
(n = 38)
Ages 9 to 10 years
(n = 23)
Females with premature adrenarche, ages 4 to 7 years
(n = 37)
Premenopausal adult females
(n = 100)
Pregnenolone (ng/dL) 26.3 (14.9-38.9) 21.45 (14.5-31.7) 25.9 (19.8-40.5) 50.6 (32.8-83.4) N/A
Progesterone (ng/dL) 5.3 (5.0-7.7) 5.1 (4.4-6.1) 4.7 (4.2-6.6) 2.7 (2.0-5.6) 88.0 (21-1017)
17-hydroxyprogesterone (ng/dL) 17.4 (10.9-28.2) 15.4 (12.8-21.8) 22.3 (13.5-34.2) 12.8 (9.5-22.1) 81 (43-141)
11-deoxycorticosterone (ng/dL) 17.3 (8.0-44.4) 7.6 (5.03-19.8) 8.1 (4.3-18.0) 7.9 (4.2-14.4) 5.0 (3.2-8.8)
Corticosterone (ng/dL) 145.4 (85.2-295.1) 113.5 (66.0-232.0) 84.2 (70.5-221.0) 92.2 (50.4-218) 253 (160-375)
11-deoxycortisol (ng/dL) 45.9 (26.6-62.7) 35.5 (22.4-51.1) 35.5 (26.3-52.4) 30.4 (19.2-48.1) 26 (15-37)
DHEA (ng/dL) 41.3 (23.0-54.7) 64.2 (43.5-141) 134.0 (84.1-186.0) 242 (162-429)

232 (155-403)

5th to 95th percentile: 121-576
Androstenedione (ng/dL) 10.4 (8.4-15.2) 15.5 (10.3-24.7) 21.2 (19.1-28.6) 17.0 (11.4-22.8)

99 (76-140)

5th to 95th percentile: 20-152
Testosterone (ng/dL) 3.8 (2.4-4.9) 4.8 (4.2-5.3) 6.3 (5.2-8.1) 5.2 (4.6-5.8)

30 (22-40)

5th to 95th percentile: <10-35
Cortisol (mcg/dL) 5.5 (3.6-9.6) 4.5 (3.5-7.1) 4.36 (3.2-9.1) 4.9 (3.4-6.5) 15.3 (11.3-21.4)
DHEAS (mcg/dL)* 5.90 (3.6-10.2)* 13.8 (7.7-35.0)* 34.6 (27.3-50.9)* 38.2 (23.0-57.1)*

116.3 (71.1-206.5)*

5th to 95th percentile: 59-303
11-hydroxyandrostenedione (ng/dL) 17.6 (11.2-34.0) 27.0 (20.0-39.7) 26.1 (17.4-44.8) 45.7 (29.3-67.5)

172 (118-261)

5th to 95th percentile: 103-423
11-ketoandrostenedione (ng/dL) 8.2 (6.8-11.2) 11.3 (9.9-14.5) 12.8 (8.7-16.8) 15.0 (12.4-22.1)

37 (26-55)

5th to 95th percentile: 48-163
11-hydroxytestosterone (ng/dL) 3.0 (2.6-6.5) 4.6 (3.2-6.7) 5.5 (4.1-6.5) 6.2 (4.9-7.4)

14 (9-23)

5th to 95th percentile: <10-21
11-ketotestosterone (ng/dL) 8.6 (7.3-10.9) 13.4 (10.3-18.1) 17.6 (14.2-22.5) 18.1 (12.3-22.9)

26 (19-38)

5th to 95th percentile: <10-48
Values are expressed as the median with interquartile range. The steroid hormones were measured using LC-MS/MS methodology[1,2]. Normal range (5th to 95th percentiles) for premenopausal adult females are also shown in italics[3].

DHEA: dehydroepiandrosterone; DHEAS: dehydroepiandrosterone sulfate; LC-MS/MS: liquid chromatography-tandem mass spectrometry.

* DHEAS values measured by immunoassay are generally higher than the LC-MS/MS results shown in this table.
Data from:
  1. Nanba AT, Rege J, Ren J, et al. 11-oxygenated C19 steroids do not decline with age in women. J Clin Endocrinol Metab 2019; 104:2615.
  2. Rege J, Turcu AF, Kasa-Vubu JZ, et al. 11-ketotestosterone is the dominant circulating bioactive androgen during normal and premature adrenarche. J Clin Endocrinol Metab 2018; 103:4589.
  3. Schiffer L, Kempegowda P, Sitch AJ, et al. Classic and 11-oxygenated androgens in serum and saliva across adulthood: A cross-sectional study analyzing the impact of age, body mass index, and diurnal and menstrual cycle variation. Eur J Endocrinol 2023; 188:lvac017.
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