Invasive breast cancer histopathologic concordance with ER staining

Highly unusual ER-negative results	Highly unusual ER-positive results
Low-grade invasive carcinomas of no special type (also known as invasive ductal carcinoma)	Metaplastic carcinomas of all subtypes
Lobular carcinomas (classic type)	Adenoid cystic carcinomas and other salivary gland-like carcinomas of the breast
Pure tubular, cribriform, or mucinous carcinomas	Secretory carcinoma
Encapsulated papillary and solid papillary carcinomas	Carcinomas with apocrine differentiation

NOTE: If a result is considered highly unusual/discordant, additional steps should be taken to check the accuracy of the histologic type or grade as well as the preanalytic and analytic testing factors. This workup may include second reviews and repeat testing. If all results appear valid, the result can be reported with a comment noting that the findings are highly unusual and testing of additional samples may be of value to confirm the findings.

ER: estrogen receptor.

Reprinted from: Allison KH, Hammond MEH, Dowsett M, et al. Estrogen and progesterone receptor testing in breast cancer. American Society of Clinical Oncology/College of American Pathologists guideline update. Arch Pathol Lab Med 2020; 144(5):545-563. With permission from Archives of Pathology & Laboratory Medicine. Copyright © 2020 College of American Pathologists.

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Invasive breast cancer histopathologic concordance with ER staining