Summary of pregnancy outcomes for women with mitral stenosis

Severity of MS	Source of data	Total number of pregnancies	Maternal outcomes			Fetal outcomes
Severity of MS	Source of data	Total number of pregnancies	Death	Pulmonary edema or heart failure	New/recurrent arrhythmias	Stillbirth	Neonatal death	Preterm birth
Mild	3 studies*^[1-3]	118	0%	18%	3%	1%	0%	8%
Moderate	Systematic review of 8 studies^[4]	287	1% (95% CI 0-2%)	18% (95% CI 2-33%)	5% (95% CI 1-9%)	2% (95% CI 1-4%)	0%	10% (95% CI 2-17%)
Severe	Systematic review of 8 studies^[4]	174	3% (95% CI 0-6%)	37% (95% CI 23-51%)	16% (95% CI 1-25%)	4% (95% CI 1-7%)	2% (95% CI 0-4%)	18% (95% CI 7-29%)

MS: mitral stenosis.
* 3 studies also included in the systematic review.

References:

Hameed A, Karaalp IS, Tummala PP, et al. The effect of valvular heart disease on maternal and fetal outcome of pregnancy. J Am Coll Cardiol 2001; 37:893.
Silversides CK, Colman JM, Sermer M, Siu SC. Cardiac risk in pregnant women with rheumatic mitral stenosis. Am J Cardiol 2003; 91:1382.
van Hagen IM, Thorne SA, Taha N, et al. Pregnancy Outcomes in Women With Rheumatic Mitral Valve Disease: Results From the Registry of Pregnancy and Cardiac Disease. Circulation 2018; 137:806.
Ducas RA, Javier DA, D'Souza R, et al. Pregnancy outcomes in women with significant valve disease: a systematic review and meta-analysis. Heart 2020; 106:512.

Graphic 130349 Version 1.0