Population-based lifetime absolute risk of breast cancer development according to age and the commonly mutated genes ATM, BRCA1, BRCA2, CHEK2, and PALB2

The CARRIERS consortium studies that were included in the analysis of the absolute risk of breast cancer among pathogenic-variant carriers were the Cancer Prevention Study II, the Cancer Prevention Study 3, the California Teachers' Study, the Mayo Clinic Breast Cancer Study, the Multiethnic Cohort Study, the Mayo Mammography Health Study, the Nurses' Health Study, the Nurses' Health Study II, the Women's Circle of Health Study, the Women's Health Initiative, and the Wisconsin Women's Health Study. The analysis in the general population was performed with the use of age-specific breast cancer incidence data (restricted to non-Hispanic White individuals) from the Surveillance, Epidemiology, and End Results 21 registries.