The morphology of circulating CAR-T cells may demonstrate activated/atypical features that should not be confused with circulating malignant cells. The first three panels illustrate circulating CAR-T cells (Wright-Giemsa stain), while the panel in the lower right illustrates flow cytometry with CD3 (vertical axis) and anti-idiotype antibody specific for CTL019 (horizontal axis).
From: Brooks S, Frey N, Porter D, et al. The cytological features of CAR(T) cells. Br J Haematol 2016; 175(3):366.
https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.14286. Copyright © 2016 John Wiley & Sons Ltd. Reproduced with permission of John Wiley & Sons Inc. This image has been provided by or is owned by Wiley. Further permission is needed before it can be downloaded to PowerPoint, printed, shared or emailed. Please contact Wiley's permissions department either via email:
[email protected] or use the RightsLink service by clicking on the 'Request Permission' link accompanying this article on Wiley Online Library (
https://onlinelibrary.wiley.com/).
