Version May 2024
| Patient weight | |||
| 15 to <25 kg | 25 to 34 kg | ≥35 kg | |
| Proton pump inhibitor (omeprazole or esomeprazole)* | 20 mg twice daily | 30 mg twice daily | 40 mg twice daily |
| Amoxicillin | |||
| Standard dose | 500 mg twice daily | 750 mg twice daily | 1000 mg twice daily |
| High dose¶Δ | 750 mg twice daily | 1000 mg twice daily | 1500 mg twice daily |
| Clarithromycin◊ | 250 mg twice daily | 500 mg AM, 250 mg PM | 500 mg twice daily |
| Metronidazole§Δ | 250 mg twice daily | 500 mg AM, 250 mg PM | 500 mg twice daily |
| Patient age | |||
| <10 years | ≥10 years | ||
| Bismuth (subsalicylate) | 262 mg 4 times daily | 524 mg 4 times daily | |
AM: morning dose; PM: evening dose.
* Dosing will be different if a proton pump inhibitor other than omeprazole or esomeprazole is used.
¶ High-dose amoxicillin is used as part of a specific regimen (with a proton pump inhibitor and metronidazole) for patients with multiple antibiotic resistance.
Δ When amoxicillin or metronidazole is used for rescue therapy (ie, if a prior attempt at treatment was unsuccessful), the UpToDate authors typically recommend higher doses, eg, amoxicillin 75 mg/kg/day divided 3 or 4 times daily or metronidazole 50 mg/kg/day divided 3 times daily. The increased frequency of dosing helps to avoid low trough levels.
◊ Clarithromycin is available as a reconstituted oral suspension. If the oral suspension is used, the total daily dose can be administered in 2 equally divided doses (ie, for patients 25 to 34 kg, administer 375 mg twice daily).
§ Metronidazole oral suspension (50 mg/mL) can be compounded by a pharmacist using oral tablets or a compounding kit. If the oral suspension is used, the total daily dose can be administered in 2 equally divided doses (ie, for patients 25 to 34 kg, administer 375 mg twice daily).آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
