Rabeprazole: Pediatric drug information

For additional information see "Rabeprazole: Drug information" and "Rabeprazole: Patient drug information"

For abbreviations, symbols, and age group definitions show table

Brand Names: US

Aciphex;
AcipHex Sprinkle [DSC]

Brand Names: Canada

APO-Rabeprazole [DSC];
DOM-Rabeprazole EC [DSC];
JAMP-RABEprazole;
Pariet;
PMS-Rabeprazole EC;
PRO-Rabeprazole [DSC];
SANDOZ Rabeprazole;
TARO-Rabeprazole [DSC];
TEVA-Rabeprazole EC [DSC]

Therapeutic Category

Gastric Acid Secretion Inhibitor;
Gastrointestinal Agent, Gastric or Duodenal Ulcer Treatment;
Proton Pump Inhibitor

Dosing: Pediatric

Gastroesophageal reflux disease, symptomatic

Gastroesophageal reflux disease, symptomatic: Note: Guidelines recommend a 4- to 8-week treatment course; if improvement seen after 4 to 8 weeks, consider possible wean; if no response after 4 to 8 weeks, reevaluate diagnosis and consider referral to pediatric GI specialist (Ref).

Infants: Limited data available: Oral: Sprinkle capsules: 5 to 10 mg once daily; dosing based on a double-blind, placebo-controlled trial which randomized patients aged 1 to 11 months (n=268) with symptomatic GERD to 10 mg, 5 mg, or placebo (n=88, n=90, n=90, respectively); the study found no difference in the degree of improvement with rabeprazole (at any dose) compared to those receiving placebo (Ref).

Children ≤11 years: Oral: Sprinkle capsules:

<15 kg: 5 mg once daily; if inadequate response may increase to 10 mg once daily.

≥15 kg: 10 mg once daily; higher doses of 20 mg/day have also been described (Ref).

Children ≥12 years and Adolescents: Oral: Tablets: 20 mg once daily.

Helicobacter pylori eradication

Helicobacter pylori eradication: Limited data available: Note: Usual duration of therapy is 14 days as part of triple therapy; use in combination with 2 antimicrobials (eg, clarithromycin, metronidazole, amoxicillin); preferred agents determined by susceptibility. Bismuth may be added to regimens as an alternative if resistance is present or susceptibility is unknown (Ref).

Children and Adolescents <16 years: Note: Dosing based on a pharmacokinetic modeling study to determine a dose that achieved AUC comparable to adults receiving 20 mg twice daily (Ref).

6 to <10 kg: Oral: 10 mg twice daily.

10 to <30 kg: Oral: 15 mg twice daily.

≥30 kg: Oral: 20 mg twice daily.

Discontinuation of therapy: Oral: Based on experience in adults, some experts recommend a step-down approach in order to avoid worsening or rebound symptoms. One recommendation is to decrease the dose by 50% over 2 to 4 weeks. If the patient is already on the lowest possible dose, alternate day therapy may be considered. If symptoms worsen during treatment or after discontinuation, patient should be reevaluated (Ref).

Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Dosing: Kidney Impairment: Pediatric

Children and Adolescents: There are no dosage adjustments provided in the manufacturer's labeling; however, pharmacokinetic studies in adults with end-stage renal disease (CrCl ≤5 mL/minute) on hemodialysis showed no clinically significant pharmacokinetic differences.

Dosing: Liver Impairment: Pediatric

Children and Adolescents:

Mild to moderate: No dosage adjustments are recommended.

Severe impairment: Avoid use; if treatment is necessary, monitor for adverse reactions.

Dosing: Adult

(For additional information see "Rabeprazole: Drug information")

Dosage guidance:

Clinical considerations: Avoid coadministration with other antisecretory agents due to decreased acid-inhibitory effects. If another antisecretory agent is needed, allow a sufficient time interval between administration (ie, morning rabeprazole and bedtime H₂RA) (Ref).

Aspiration prophylaxis in patients undergoing anesthesia

Aspiration prophylaxis in patients undergoing anesthesia (off-label use):

Note: May be considered in patients at high risk for aspiration (Ref).

Oral: 20 mg given the night before surgery and 20 mg given the morning of surgery (Ref).

Barrett esophagus

Barrett esophagus (off-label use):

Oral: 20 mg once daily; may increase the dose to 20 to 40 mg twice daily if needed to eliminate gastroesophageal reflux disease (GERD) symptoms or heal reflux esophagitis. Long-term maintenance therapy is recommended (Ref).

Dyspepsia, functional

Dyspepsia, functional (off-label use):

Note: For patients who test negative for H. pylori infection or have persistent symptoms following H. pylori eradication (Ref).

Oral: 20 mg once daily for up to 8 weeks (Ref); can be continued for a longer duration in patients with symptom improvement. Some experts recommend attempting to discontinue every 6 to 12 months to minimize the long-term risk of therapy (Ref).

Eosinophilic esophagitis

Eosinophilic esophagitis (off-label use): Oral: 20 mg twice daily for an 8-week trial (Ref). Once 8-week trial is complete and remission is achieved, the dose may be gradually lowered to an individualized maintenance level (Ref). Some experts initiate with 20 mg once daily and increase to twice-daily dosing after 4 weeks if symptoms fail to improve (Ref).

Gastroesophageal reflux disease

Gastroesophageal reflux disease (GERD):

Initial therapy:

Mild/intermittent disease (<2 episodes/week) and no evidence of erosive esophagitis:

Note: Some experts reserve proton pump inhibitors (PPIs) for patients who have residual acid reflux symptoms despite twice-daily H₂RA (Ref).

Oral: 20 mg once daily. Where available, may start with 10 mg once daily and increase to 20 mg once daily after 4 to 8 weeks, if necessary. Discontinue once asymptomatic for 8 weeks (Ref).

Severe and/or frequent symptoms (≥2 episodes/week), and/or erosive esophagitis:

Oral: 20 mg once daily; once symptoms are controlled, continue for at least 8 weeks (Ref). Subsequently, patients without erosive esophagitis or Barrett esophagus can taper to the lowest dose necessary to control symptoms (and/or switch to an H₂RA blocker), then discontinue acid suppression once asymptomatic. Patients with erosive esophagitis or Barrett esophagus should continue long-term maintenance therapy with 20 mg once daily (Ref).

Residual symptoms despite 20 mg once daily therapy:

Note: Referral to a specialist is recommended.

Oral: Options include splitting the dose to 10 mg twice daily, increasing the dose to 20 mg twice daily, or switching to another PPI (Ref).

Helicobacter pylori eradication

Helicobacter pylori eradication:

Oral: 20 or 40 mg twice daily for 14 days as part of an appropriate combination regimen with antibiotics. Dose depends on selected regimen (Ref).

Hypersecretory conditions

Hypersecretory conditions (including Zollinger-Ellison syndrome): Oral: Initial: 60 mg once daily. If needed, may titrate upward early in therapy, using divided doses as appropriate; once acid output has been controlled, gradual dose reductions are usually possible; continue as long as clinically indicated (Ref). Doses as high as 100 mg once daily and 60 mg twice daily have been used.

NSAID-induced ulcers, primary prevention

NSAID (including aspirin)-induced ulcers, primary prevention (off-label use):

Note: For select patients at moderate or high risk for GI toxicity. These include patients with a history of GI ulcer, on dual antiplatelet therapy (eg, aspirin plus a P2Y12 inhibitor), on concurrent anticoagulant therapy, or with multiple additional risk factors (eg, corticosteroid use, high nonsteroidal anti-inflammatory drug [NSAID] dose, H. pylori infection) (Ref). For patients on dual antiplatelet therapy, some experts reserve prophylaxis for those with additional risk factors (Ref). If present, H. pylori infection should be treated first (Ref).

Oral: 20 mg once daily for the duration of high-risk NSAID use. Where available, may consider 10 mg once daily (Ref).

Peptic ulcer disease, treatment and secondary prevention

Peptic ulcer disease, treatment and secondary prevention:

Note: For patients on NSAIDs (including aspirin), the NSAID should be discontinued, if possible (Ref). If present, H. pylori infection should be treated first; uncomplicated H. pylori–associated ulcers may not need PPI treatment beyond that included in the eradication regimen (Ref).

Uncomplicated ulcer: Oral: 20 mg once daily. Duration depends on the size, location, and cause of ulcer and ranges from 4 to 8 weeks. In patients with refractory or recurrent disease, may increase the dose to 20 mg twice daily (Ref).

Complicated ulcer (perforation, penetration, or gastric outlet obstruction) (off-label use): Oral: 20 mg twice daily for 2 weeks, followed by 20 mg once daily. Duration depends on the location and etiology of ulcer (Ref).

Bleeding ulcer:

Initial therapy: Note: Optimal pre-endoscopic PPI therapy is uncertain. Some experts suggest initiating therapy with a high-dose IV PPI using continuous or intermittent dosing in patients with suspected active upper GI bleed prior to endoscopy (Ref). Following endoscopy, for patients with high-risk stigmata of recent bleeding (eg, active bleed, visible vessel, adherent clot), a continuous infusion of an IV PPI for at least 72 hours before transitioning to an oral PPI is recommended (Ref). Patients without high-risk stigmata of recent bleeding can be switched to an oral PPI immediately after endoscopy (Ref).

Patients with high-risk stigmata of recent bleeding on endoscopy (following IV PPI therapy): Oral: 20 mg twice daily to complete 14 days of twice-daily PPI therapy, followed by 20 mg once daily (Ref).

Patients with no high-risk stigmata of recent bleeding on endoscopy: Oral: 20 mg once daily (Ref).

Duration: The total duration of treatment depends on size, location, and cause of the ulcer and ranges from 4 to 12 weeks (Ref).

Maintenance therapy/secondary prevention (off-label use):

Note: For select high-risk patients (eg, idiopathic ulcers, frequently recurrent ulcers, need for continued NSAID use).

Oral: 20 mg once daily for 12 to 24 weeks or as long as the NSAID is used (Ref); where available, may consider 5 or 10 mg once daily (Ref).

Discontinuation of therapy: Oral: In patients who have received continuous therapy for >6 months, some experts gradually taper therapy until discontinuation to avoid worsening or rebound GERD symptoms. There is no single agreed upon discontinuation strategy. If the patient is receiving 20 mg once or twice daily, some experts decrease the dose by 50% every week. For patients receiving twice-daily dosing, the first dose reduction can be achieved by decreasing to once-daily AM dosing. Once patients are on the lowest dose for 1 week, discontinue therapy (Ref). An alternative strategy is to decrease the dose by 50% over 2 weeks to 4 weeks, then discontinue. If the patient is already on the lowest possible dose, alternate day therapy may be considered (Ref). In addition, as-needed therapy with an H₂RA or an antacid can be used during the taper (Ref).

Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Dosing: Kidney Impairment: Adult

No dosage adjustment necessary.

Dosing: Liver Impairment: Adult

Mild-to-moderate impairment (Child-Pugh class A or B): No dosage adjustment necessary.

Severe impairment (Child-Pugh class C): Avoid use; if treatment is necessary, monitor for adverse reactions.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. As reported for adults unless otherwise specified.

>10%: Gastrointestinal: Abdominal pain (children: 16%; adolescents and adults: ≤4%), diarrhea (children and adolescents: 5% to 21%; adults: <2%), vomiting (children: 10% to 14%; adolescents: 4%)

1% to 10%:

Cardiovascular: Peripheral edema (<2%)

Gastrointestinal: Constipation (2%), flatulence (3%), nausea (children and adolescents: 2% to 9%), xerostomia (<2%)

Hepatic: Hepatic encephalopathy (<2%), hepatitis (<2%), increased liver enzymes (<2%)

Infection: Infection (2%)

Nervous system: Dizziness (<2%), headache (children and adolescents: 5% to 10%; adults: <2%), pain (3%)

Neuromuscular & skeletal: Arthralgia (<2%), myalgia (<2%)

Respiratory: Pharyngitis (3%)

Postmarketing:

Dermatologic: Acute generalized exanthematous pustulosis, bullous rash, cutaneous lupus erythematous, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis

Endocrine & metabolic: Hyperammonemia, hypocalcemia, hypokalemia, hypomagnesemia, hyponatremia, increased thyroid stimulating hormone level

Gastrointestinal: Clostridioides difficile-associated diarrhea, colitis (microscopic) (Verhaegh 2016)

Genitourinary: Erectile dysfunction

Hematologic & oncologic: Agranulocytosis, hemolytic anemia, leukopenia, pancytopenia, polyp (fundic gland), thrombocytopenia

Hepatic: Hepatotoxicity (idiosyncratic) (Chalasani 2014), jaundice

Hypersensitivity: Anaphylaxis, angioedema, drug reaction with eosinophilia and systemic symptoms

Nervous system: Coma, delirium, disorientation, vertigo

Neuromuscular & skeletal: Bone fracture, rhabdomyolysis, systemic lupus erythematosus

Ophthalmic: Blurred vision

Renal: Interstitial nephritis (including acute interstitial nephritis), kidney disease (chronic; Lazarus 2016)

Respiratory: Pneumonia (interstitial)

Contraindications

Hypersensitivity (eg, anaphylaxis, anaphylactic shock, angioedema, bronchospasm, acute tubulointerstitial nephritis, urticaria) to rabeprazole, other substituted benzimidazoles, or any component of the formulation; concomitant use with rilpivirine-containing products.

Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Warnings/Precautions

Concerns related to adverse effects:

• Atrophic gastritis: Long-term omeprazole therapy has caused atrophic gastritis (by biopsy); this may also occur with rabeprazole.

• Carcinoma: No reports of adenomatoid, dysplastic or neoplastic changes of enterochromaffin-like (ECL) cells in the gastric mucosa have occurred.

• Clostridioides difficile-associated diarrhea (CDAD): Use of proton pump inhibitors (PPIs) may increase risk of CDAD, especially in hospitalized patients; consider CDAD diagnosis in patients with persistent diarrhea that does not improve. Use the lowest dose and shortest duration of PPI therapy appropriate for the condition being treated.

• Cutaneous and systemic lupus erythematosus: Has been reported as new onset or exacerbation of existing autoimmune disease; most cases were cutaneous lupus erythematosus (CLE), most commonly, subacute CLE (occurring within weeks to years after continuous therapy). Systemic lupus erythematosus (SLE) is less common (typically occurs within days to years after initiating treatment) and occurred primarily in young adults up to the elderly. Discontinue therapy if signs or symptoms of CLE or SLE occur and refer to specialist for evaluation; most patients improve 4 to 12 weeks after discontinuation of rabeprazole.

• Dermatologic reactions: Severe cutaneous adverse reactions, including acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necrolysis, have been reported.

• Fractures: Increased incidence of osteoporosis-related bone fractures of the hip, spine, or wrist may occur with proton pump inhibitor (PPI) therapy. Patients on high-dose (multiple daily doses) or long-term therapy (≥1 year) should be monitored. Use the lowest effective dose for the shortest duration of time, use vitamin D and calcium supplementation, and follow appropriate guidelines to reduce risk of fractures in patients at risk.

• Fundic gland polyps: Use of PPIs increases risk of fundic gland polyps, especially with long term use (>1 year). May occur without symptoms but nausea, vomiting, or abdominal pain may occur; gastrointestinal bleeding and/or anemia may occur with ulcerated polyps. Diagnosis of polyps may also increase risk for small intestinal blockage. Use the lowest dose and shortest duration of PPI therapy appropriate for the condition being treated.

• Gastrointestinal infection (eg, Salmonella, Campylobacter): Use of proton pump inhibitors may increase risk of these infections.

• Hypomagnesemia: Reported rarely, usually with prolonged PPI use of ≥3 months (most cases >1 year of therapy). May be symptomatic or asymptomatic; severe cases may cause tetany, seizures, and cardiac arrhythmias. Hypomagnesemia may lead to or exacerbate hypocalcemia in patients at risk (eg, hypoparathyroidism). Hypomagnesemia may also lead to hypokalemia. Hypomagnesemia and hypocalcemia may be corrected by magnesium/calcium supplementation, although discontinuation of rabeprazole may be necessary.

• Tubulointerstitial nephritis: Acute tubulointerstitial nephritis has been observed in patients taking PPIs; may occur at any time during therapy. Patients may present with symptomatic hypersensitivity reaction to nonspecific symptoms of impaired renal function (eg, anorexia, malaise, nausea); may be diagnosed with biopsy and in the absence of extra-renal manifestations (eg, fever, rash, arthralgia). Discontinue and evaluate patients if acute tubulointerstitial nephritis is suspected.

• Vitamin B₁₂ deficiency: Prolonged treatment (>3 years) may lead to vitamin B₁₂ malabsorption and subsequent vitamin B₁₂ deficiency. The magnitude of the deficiency is dose-related and the association is stronger in females and those younger in age (<30 years of age); prevalence is decreased after discontinuation of therapy (Lam 2013).

Disease-related concerns:

• Gastric malignancy: Relief of symptoms does not preclude the presence of a gastric malignancy.

• Hepatic impairment: Avoid use in patients with severe hepatic impairment; if treatment is necessary monitor for adverse reactions.

Concurrent drug therapy issues:

• Clopidogrel: PPIs may diminish the therapeutic effect of clopidogrel, thought to be due to reduced formation of the active metabolite of clopidogrel. The manufacturer of clopidogrel recommends either avoidance of both omeprazole (even when scheduled 12 hours apart) and esomeprazole or use of a PPI with comparatively less effect on the active metabolite of clopidogrel. Avoidance of rabeprazole appears prudent due to potent in vitro CYP2C19 inhibition (Li 2004) and lack of sufficient comparative in vivo studies with other PPIs. In contrast to these warnings, others have recommended the continued use of PPIs, regardless of the degree of inhibition, in patients with a history of GI bleeding or multiple risk factors for GI bleeding who are also receiving clopidogrel since no evidence has established clinically meaningful differences in outcome; however, a clinically significant interaction cannot be excluded in those who are poor metabolizers of clopidogrel (Abraham 2010; Levine 2011).

Special populations:

• Bariatric surgery: Presurgical assessment of the indication for use, symptoms, and goals of therapy should be documented to enable postsurgical assessment. Monitor for continued efficacy after bariatric surgery and consider switching to an alternative medication if symptoms worsen.

Warnings: Additional Pediatric Considerations

Use of gastric acid inhibitors, including proton pump inhibitors (PPIs) and H₂ blockers, has been associated with an increased risk for development of acute gastroenteritis and community-acquired pneumonia in pediatric patients 4 to 36 months of age (Canani 2006). Routine use in preterm infants is not recommended (AAP [Eichenwald 2018]).

Gastric acid suppression medications have been associated with an increase in Clostridioides difficile infection (CDI) and recurrent CDI in pediatric patients (Nylund 2014). In a retrospective, observational, case control study of pediatric patients 1 to 18 years old who were hospitalized for diarrhea and abdominal pain, the use of PPIs was significantly higher in patients who tested positive for C. difficile compared to patients who tested negative for C. difficile (22.1% vs 5.9%) (Turco 2010). Consider CDI diagnosis in patients with persistent diarrhea that does not improve. Use the lowest dose and shortest duration of PPI therapy appropriate for the condition being treated.

A large retrospective cohort study reviewed records for patients with a low baseline risk for fractures who were initiated on acid suppression therapy in the first year of life and evaluated the fracture risk in the first 5 years of life; a total of 97,286 patients were prescribed acid suppression therapy; 73% were prescribed H₂ blockers, 9% were prescribed PPIs, and 18% were prescribed both. H₂ blocker use alone was not associated with an increased fracture hazard; however, PPI use was associated with a 21% increase and use of PPI plus H₂ blocker was associated with a 30% increase. Longer duration of therapy and earlier age at initiation seemed to also increase the fracture hazard. Study findings do not establish a causal relationship between PPI use and fractures. If acid suppression therapy is necessary in the first year of life, limiting therapy to a single drug and limiting the duration should be considered (Malchodi 2019). A second large cohort study reviewed records for 115,933 children <18 years initiated on a PPI. PPI initiation was associated with a statistically significant 11% relative increase in risk of any fracture in patients ≥6 years. The increased risk also seemed to be more pronounced with a longer cumulative duration of PPI use (Wang 2020).

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Capsule Sprinkle, Oral, as sodium:

AcipHex Sprinkle: 5 mg [DSC] [contains carrageenan, fd&c blue #2 (indigo carm) aluminum lake]

AcipHex Sprinkle: 10 mg [DSC] [contains carrageenan, fd&c yellow #6 (sunset yellow)]

Generic: 10 mg

Tablet Delayed Release, Oral, as sodium:

Aciphex: 20 mg

Generic: 20 mg

Generic Equivalent Available: US

Yes

Pricing: US

Capsule, sprinkles (RABEprazole Sodium Oral)

10 mg (per each): $49.67

Tablet, EC (Aciphex Oral)

20 mg (per each): $43.56

Tablet, EC (RABEprazole Sodium Oral)

20 mg (per each): $10.19 - $11.46

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Tablet Delayed Release, Oral:

Pariet: 10 mg

Generic: 10 mg

Tablet Delayed Release, Oral, as sodium:

Pariet: 20 mg

Generic: 20 mg

Administration: Pediatric

The following recommendations are based upon the best available evidence and clinical expertise. Senior editorial team: Joseph I. Boullata, PharmD, RPh, CNS-S, FASPEN, FACN; Peggi A. Guenter PhD, RN, FASPEN; Kathleen Gura, PharmD, BCNSP, FASHP, FASPEN, FPPA, FMSHP; Mark G. Klang, MS, RPh, BCNSP, PhD, FASPEN; Linda Lord, NP, ACNP-BC, CNSC, FASPEN; Lucas E. Orth, PharmD, BCPPS; Russel J. Roberts, PharmD, BCCCP, FCCM.

Note: Recommendations may not account for differences in inactive ingredients, osmolality, or other formulation properties that may vary among products from different manufacturers.

Oral: May administer with an antacid.

Sprinkle capsules, delayed release: Administer 30 minutes before a meal. Do NOT swallow capsule whole. Open capsule and sprinkle contents on a small amount of soft food (eg, applesauce, fruit- or vegetable-based baby food, yogurt) or empty contents into a small amount of liquid (eg, infant formula, apple juice, pediatric electrolyte solution); food or liquid should be at or below room temperature. Do not chew or crush granules; administer whole dose within 15 minutes of preparation; do not store for future use.

Administration via feeding tube: NOT recommended: Other proton pump inhibitors are preferred for administration via enteral feeding tube (Ref). Crushing contents of delayed-release sprinkle capsules may cause gastric degradation of the active ingredient and decreased bioavailability. Additionally, enteric coating may clump and cause enteral feeding tube obstruction (Ref).

Tablets, delayed release: Tablets should be swallowed whole; do not chew, crush, or split. May be administered without regard to food; best if taken 30 minutes before a meal when treating gastroesophageal reflux disease (GERD) (Ref).

Administration via feeding tube: NOT recommended: Other proton pump inhibitors are preferred for administration via enteral feeding tube (Ref). Crushing delayed-release tablets may cause gastric degradation of the active ingredient and decreased bioavailability. Additionally, enteric coating may clump and cause enteral feeding tube obstruction (Ref). Note: An extemporaneously compounded mixture using delayed-release tablets and sodium bicarbonate has been suggested and may be considered when alternatives are not available (Ref).

Administration: Adult

Oral: May be administered with an antacid.

Capsules: Administer 30 minutes before a meal. Open capsule and sprinkle entire contents on a small amount of soft food (eg, applesauce, fruit or vegetable based baby food, yogurt) or empty contents into a small amount of liquid (eg, infant formula, apple juice, pediatric electrolyte solution); food or liquid should be at or below room temperature. Do not swallow capsule whole, or chew or crush granules; administer whole dose within 15 minutes of preparation (do not store for future use).

Tablets: Swallow whole; do not crush, split, or chew; may administer with or without food. However, when used for the treatment of duodenal ulcers, administer after a meal; when used for the eradication of H. pylori, administer with the morning and evening meals.

Bariatric surgery: Rabeprazole is available as delayed release formulations. Bariatric surgery may significantly alter the release characteristics in an unknown manner. Providers should determine if the condition being treated can be safely monitored or if a switch to an alternative medication is necessary (Ref).

Enteral feeding tube:

The following recommendations are based upon the best available evidence and clinical expertise. Senior editorial team: Joseph I. Boullata, PharmD, RPh, CNS-S, FASPEN, FACN; Peggi A. Guenter, PhD, RN, FASPEN; Kathleen Gura, PharmD, BCNSP, FASHP, FASPEN, FPPA, FMSHP; Mark G. Klang, MS, RPh, BCNSP, PhD, FASPEN; Linda Lord, NP, ACNP-BC, CNSC, FASPEN; Lucas E. Orth, PharmD, BCPPS; Russel J. Roberts, PharmD, BCCCP, FCCM.

Note: Other proton pump inhibitors are preferred for administration via enteral feeding tube (EFT) (Ref).

Oral sprinkle capsule, delayed release; oral tablet, delayed release:

EFT administration utilizing rabeprazole delayed-release tablets or delayed-release sprinkle capsules is not recommended. Crushing modified-release dosage forms (eg, delayed-release rabeprazole tablets or delayed-release sprinkle capsules) may cause gastric degradation of the active ingredient and decreased bioavailability. Additionally, enteric coating may clump and cause EFT obstruction (Ref). Note: An extemporaneously compounded mixture using delayed-release tablets and sodium bicarbonate has been suggested and may be considered when alternatives are not available (Ref).

No te: Recommendations may not account for differences in inactive ingredients, osmolality, or other formulation properties that may vary among products from different manufacturers.

Storage/Stability

Store at 25°C (77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F). Protect from moisture.

Medication Guide and/or Vaccine Information Statement (VIS)

An FDA-approved patient medication guide, which is available with the product information and as follows, must be dispensed with this medication:

Aciphex: https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/020973s043lbl.pdf#page=34

Aciphex Sprinkle: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/204736s012lbl.pdf#page=21

Use

Treatment of symptomatic gastroesophageal reflux disease (GERD) (Sprinkle capsule: FDA approved in ages 1 to ≤11 years; Tablets: FDA approved in ages ≥12 years and adults); short-term treatment (4 to 8 weeks) and maintenance of erosive or ulcerative GERD (Tablets: FDA approved in adults); short-term treatment (4 weeks) of duodenal ulcers (Tablets: FDA approved in adults); long-term treatment of pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome) (Tablets: FDA approved in adults); treatment of Helicobacter pylori infection and duodenal ulcer disease (active or history of within the past 5 years) as part of an appropriate combination regimen with antibiotics (Tablets: FDA approved in adults).

Medication Safety Issues

Sound-alike/look-alike issues:

AcipHex may be confused with Acephen, Accupril, Aricept, pHisoHex

RABEprazole may be confused with ARIPiprazole, donepezil, lansoprazole, omeprazole, raloxifene

Older Adult: High-Risk Medication:

Beers Criteria: Rabeprazole is identified in the Beers Criteria as a potentially inappropriate medication to be avoided (as scheduled use for >8 weeks) in patients 65 years and older due to its risk of C. difficile infection, pneumonia, GI malignancies, and bone loss/fractures unless given for high-risk patients (eg, oral corticosteroid or chronic NSAID use), patients with erosive esophagitis, Barrett's esophagitis, a pathological hypersecretory condition, or if the patient has demonstrated a need for maintenance therapy (eg, failure of drug discontinuation trial or failure of H₂ blockers) (Beers Criteria [AGS 2023]).

Metabolism/Transport Effects

Substrate of CYP2C19 (Minor), CYP3A4 (Minor); Note: Assignment of Major/Minor substrate status based on clinically relevant drug interaction potential; Inhibits OAT1/3;

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program

Acalabrutinib: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Acalabrutinib. This interaction is only applicable to acalabrutinib capsules. Risk X: Avoid

Afatinib: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease therapeutic effects of Afatinib. Risk C: Monitor

Amphetamines: Inhibitors of the Proton Pump (PPIs and PCABs) may increase absorption of Amphetamines. Specifically, the amphetamine absorption rate may be increased in the first hours after dosing. Risk C: Monitor

Atazanavir: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Atazanavir. Management: Avoid use in treatment-experienced patients. In treatment-naive patients, administer boosted atazanavir 12 hours after the PPI and the PPI dose should not exceed the equivalent of 20 mg omeprazole. Monitor for reduced atazanavir efficacy. Risk D: Consider Therapy Modification

Belumosudil: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Belumosudil. Management: Increase the dose of belumosudil to 200 mg twice daily when coadministered with inhibitors of the proton pump (PPIs and PCABs). Risk D: Consider Therapy Modification

Bisphosphonate Derivatives: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease therapeutic effects of Bisphosphonate Derivatives. Risk C: Monitor

Bosutinib: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Bosutinib. Management: Consider alternatives to proton pump inhibitors and potassium-competitive acid blockers, such as short-acting antacids or histamine-2 receptor antagonists. Administer alternative agents more than 2 hours before or after bosutinib. Risk D: Consider Therapy Modification

Capecitabine: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease therapeutic effects of Capecitabine. Risk C: Monitor

Cefditoren: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Cefditoren. Risk X: Avoid

Cefpodoxime: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Cefpodoxime. Risk C: Monitor

Cefuroxime: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease absorption of Cefuroxime. Management: Avoid concomitant use of oral cefuroxime axetil and proton pump inhibitors (PPIs) or potassium-competitive acid blockers (PCABs) when possible. If combined, ensure oral cefuroxime axetil is taken with food to minimize the magnitude of this interaction. Risk D: Consider Therapy Modification

Clofarabine: OAT1/3 Inhibitors may increase serum concentration of Clofarabine. Risk C: Monitor

Cysteamine (Systemic): Inhibitors of the Proton Pump (PPIs and PCABs) may decrease therapeutic effects of Cysteamine (Systemic). Risk C: Monitor

Dacomitinib: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Dacomitinib. Management: Avoid concurrent use of dacomitinib with PPIs and PCABs. Antacids may be used. Histamine H2-receptor antagonists (HR2A) may be used if dacomitinib is given at least 6 hours before or 10 hours after the H2RA. Risk X: Avoid

Dasatinib: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Dasatinib. Management: Do not administer PPIs/PCABs with dasatinib. Antacids (taken 2 hours before or after dasatinib) can be used instead if some acid-reducing therapy is needed. No interaction is expected with the Phyrago brand of dasatinib. Risk X: Avoid

Dichlorphenamide: OAT1/3 Inhibitors may increase serum concentration of Dichlorphenamide. Risk C: Monitor

Doxycycline: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease bioavailability of Doxycycline. Risk C: Monitor

Erlotinib: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Erlotinib. Risk X: Avoid

Gefitinib: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Gefitinib. Management: Avoid use of inhibitors of the proton pump (PPIs or PCABs) with gefitinib when possible. If required, administer gefitinib 12 hours after the PPI/PCAB or 12 hours before the next dose of the PPI/PCAB. Closely monitor clinical response to gefitinib. Risk D: Consider Therapy Modification

Immune Checkpoint Inhibitors (Anti-PD-1, -PD-L1, and -CTLA4 Therapies): Inhibitors of the Proton Pump (PPIs and PCABs) may decrease therapeutic effects of Immune Checkpoint Inhibitors (Anti-PD-1, -PD-L1, and -CTLA4 Therapies). Risk C: Monitor

Indinavir: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Indinavir. Risk C: Monitor

Itraconazole: Inhibitors of the Proton Pump (PPIs and PCABs) may increase serum concentration of Itraconazole. This specifically applies to the super bioavailable itraconazole products (eg, Tolsura brand). Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Itraconazole. This specifically applies to the non-super bioavailable itraconazole products (eg, Sporanox brand and its generics). Management: Exposure to Tolsura brand itraconazole may be increased by PPIs or PCABs ; consider itraconazole dose reduction. Exposure to Sporanox brand itraconazole may be decreased. Give Sporanox brand itraconazole at least 2 hrs before or 2 hrs after PPIs or PCABs. Risk D: Consider Therapy Modification

Ketoconazole (Systemic): May increase serum concentration of Inhibitors of the Proton Pump (PPIs and PCABs). Inhibitors of the Proton Pump (PPIs and PCABs) may decrease absorption of Ketoconazole (Systemic). Management: Administer ketoconazole with an acidic beverage, such as non-diet cola, to increase gastric acidity and improve absorption if concomitant use with proton pump inhibitors or potassium-competitive acid blockers is necessary. Risk D: Consider Therapy Modification

Ledipasvir: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Ledipasvir. Management: PPI or PCAB doses equivalent to omeprazole 20 mg or lower may be given with ledipasvir under fasted conditions. Use of ledipasvir with higher doses or with food, or 2 hours after a these agents, may reduce ledipasvir bioavailability. Risk D: Consider Therapy Modification

Levoketoconazole: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease absorption of Levoketoconazole. Levoketoconazole may increase serum concentration of Inhibitors of the Proton Pump (PPIs and PCABs). Risk X: Avoid

Lumacaftor and Ivacaftor: May decrease serum concentration of Inhibitors of the Proton Pump (PPIs and PCABs). Risk C: Monitor

Methotrexate: Inhibitors of the Proton Pump (PPIs and PCABs) may increase serum concentration of Methotrexate. Management: Consider temporarily interrupting PPI or PCAB therapy in patients receiving high-dose methotrexate. If coadministered, monitor for increased methotrexate toxicity (eg, mucositis, myalgias) and/or delayed methotrexate elimination. Risk D: Consider Therapy Modification

Multivitamins/Minerals (with ADEK, Folate, Iron): Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Multivitamins/Minerals (with ADEK, Folate, Iron). Specifically, the absorption of iron may be decreased. Risk C: Monitor

Mycophenolate: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Mycophenolate. Specifically, concentrations of the active mycophenolic acid may be reduced. Risk C: Monitor

Nelfinavir: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Nelfinavir. Inhibitors of the Proton Pump (PPIs and PCABs) may decrease active metabolite exposure of Nelfinavir. Management: Due to potentially significant reductions in nelfinavir exposure, avoid concurrent use of nelfinavir with a PPI or PCAB when possible. If unavoidable, consider PPI or PCAB use for a short duration (less than 30 days) and closely monitor viral load. Risk D: Consider Therapy Modification

Neratinib: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Neratinib. Specifically, proton pump inhibitors may reduce neratinib absorption. Risk X: Avoid

Nilotinib: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Nilotinib. Management: Avoid this combination. Histamine H2 receptor antagonists (H2RAs) given 10 hours before or 2 hours after nilotinib, or antacids given 2 hours before or 2 hours after nilotinib are acceptable alternatives. Risk X: Avoid

Nirogacestat: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Nirogacestat. Risk X: Avoid

Octreotide: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Octreotide. Risk C: Monitor

Palbociclib: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease therapeutic effects of Palbociclib. Specifically, this has been reported with the use of palbociclib capsules. Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Palbociclib. Specifically, this may occur with the use of palbociclib capsules, and to the greatest extent when taken without food. Management: Carefully evaluate potential risks and benefits of coadministration of palbociclib capsules and proton pump inhibitors or potassium-competitive acid blockers due to the risk of reduced palbociclib efficacy. Palbociclib capsules should be taken with food. Risk D: Consider Therapy Modification

PAZOPanib: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of PAZOPanib. Risk X: Avoid

PEMEtrexed: Inhibitors of the Proton Pump (PPIs and PCABs) may increase adverse/toxic effects of PEMEtrexed. Specifically, the risk of hematological toxicities may be increased. Risk C: Monitor

Pexidartinib: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Pexidartinib. Management: Avoid this combination. If acid-reduction is needed, consider administering an antacid 2 hours before or after pexidartinib, or administer pexidartinib 2 hours before or 10 hours after an H2 receptor antagonist. Risk X: Avoid

Posaconazole: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Posaconazole. Management: Avoid coadministration of PPIs or PCABs and posaconazole oral suspension. Posaconazole delayed-release tablets do not appear to be sensitive to this interaction and do not required dose adjustment if coadministered with PPIs or PCABs. Risk D: Consider Therapy Modification

Rilpivirine: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Rilpivirine. Risk X: Avoid

Riociguat: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Riociguat. Risk C: Monitor

Risedronate: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease therapeutic effects of Risedronate. Inhibitors of the Proton Pump (PPIs and PCABs) may increase serum concentration of Risedronate. This applies specifically to use of delayed-release risedronate. Management: Coadministration of PPIs or PCABs with delayed-release risedronate formulations is not recommended. Limit PPI/PCAB dose and duration during coadministration with risedronate as possible. Patients over age 70 are at higher risk of adverse effects. Risk D: Consider Therapy Modification

Saquinavir: Inhibitors of the Proton Pump (PPIs and PCABs) may increase serum concentration of Saquinavir. Risk C: Monitor

Secretin: Coadministration of Inhibitors of the Proton Pump (PPIs and PCABs) and Secretin may alter diagnostic results. Specifically, use of PPIs may cause a hyperresponse in gastrin secretion in response to secretin stimulation testing, falsely suggesting gastrinoma. Management: Avoid concomitant use of PPIs or PCABs and secretin, and discontinue PPI or PCAB several weeks prior to secretin administration, with the duration of separation determined by the specific acid suppressant. See full monograph for details. Risk D: Consider Therapy Modification

Seladelpar: OAT1/3 Inhibitors may increase serum concentration of Seladelpar. Risk X: Avoid

Selpercatinib: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Selpercatinib. Management: Coadministration of selpercatinib and PPIs or PCABs should be avoided. If coadministration cannot be avoided, selpercatinib and PPIs or PCABs should be administered simultaneously with food. Risk D: Consider Therapy Modification

SORAfenib: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease absorption of SORAfenib. Risk C: Monitor

Sotorasib: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Sotorasib. Risk X: Avoid

Sparsentan: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Sparsentan. Risk X: Avoid

Sulopenem Etzadroxil: OAT1/3 Inhibitors may increase serum concentration of Sulopenem Etzadroxil. Risk C: Monitor

Sulpiride: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Sulpiride. Management: Consider alternatives to this combination due to the possibility of reduced sulpiride absorption and efficacy. If gastric acid suppressing therapy is required, consider use of antacids administered at least 2 hours after sulpiride. Risk D: Consider Therapy Modification

Tacrolimus (Systemic): Inhibitors of the Proton Pump (PPIs and PCABs) may increase serum concentration of Tacrolimus (Systemic). Risk C: Monitor

Technetium Tc 99m Sestamibi: Coadministration of Inhibitors of the Proton Pump (PPIs and PCABs) and Technetium Tc 99m Sestamibi may alter diagnostic results. Management: Consider holding/stopping proton pump inhibitor therapy for at least 3 days prior to the use technetium Tc 99m sestamibi in cardiac imaging procedures. Risk D: Consider Therapy Modification

Technetium Tc 99m Tetrofosmin: Coadministration of Inhibitors of the Proton Pump (PPIs and PCABs) and Technetium Tc 99m Tetrofosmin may alter diagnostic results. Risk C: Monitor

Thiazolidinediones: Inhibitors of the Proton Pump (PPIs and PCABs) may increase adverse/toxic effects of Thiazolidinediones. Specifically, the risk of osteoporosis or fracture may be increased. Risk C: Monitor

Tipranavir: May decrease serum concentration of Inhibitors of the Proton Pump (PPIs and PCABs). These data are derived from studies with Ritonavir-boosted Tipranavir. Risk C: Monitor

Vadadustat: OAT1/3 Inhibitors may increase serum concentration of Vadadustat. Risk C: Monitor

Velpatasvir: Inhibitors of the Proton Pump (PPIs and PCABs) may decrease serum concentration of Velpatasvir. Management: Sofosbuvir/velpatasvir should be administered with food and taken 4 hours before omeprazole 20 mg. Sofosbuvir/velpatasvir/voxilaprevir can be administered with omeprazole 20 mg. Use with other PPIs or PCABs has not been studied. Risk D: Consider Therapy Modification

Voriconazole: May increase serum concentration of Inhibitors of the Proton Pump (PPIs and PCABs). Inhibitors of the Proton Pump (PPIs and PCABs) may increase serum concentration of Voriconazole. Risk C: Monitor

Food Interactions

Prolonged treatment (≥2 years) may lead to malabsorption of dietary vitamin B₁₂ and subsequent vitamin B₁₂ deficiency (Lam, 2013).

Dietary Considerations

Capsules: Take 30 minutes before a meal.

Tablets: When used for the treatment of duodenal ulcers, administer after a meal; when used for the eradication of Helicobacter pylori, administer with the morning and evening meals.

Pregnancy Considerations

Outcome data following use of proton pump inhibitors (PPIs) during pregnancy are available (Choi 2023; Hussain 2022; Peron 2023). Based on available studies, an increased risk of adverse pregnancy outcomes has not been observed following maternal use of rabeprazole.

Recommendations for the treatment of gastroesophageal reflux disease in pregnant patients are available. When initiating treatment during pregnancy, a step-up approach, starting with diet and lifestyle modifications, is recommended. Proton pump inhibitors are considered acceptable for use during pregnancy when other medications are not effective (Ali 2022; Dunbar 2022; Thélin 2020).

Monitoring Parameters

Magnesium (baseline and periodically thereafter, especially in patients receiving digoxin or drugs known to cause hypomagnesemia [eg, diuretics] or who are receiving prolonged treatment); calcium (baseline and periodically in patients at risk [eg, hypoparathyroidism]); susceptibility testing recommended in patients in whom H. pylori eradication regimen fails.

Mechanism of Action

Potent proton pump inhibitor; suppresses gastric acid secretion by inhibiting the parietal cell H+/K+ ATP pump

Pharmacokinetics (Adult Data Unless Noted)

Onset of action: Within 1 hour

Duration: 24 hours

Absorption: Oral: Well absorbed within 1 hour; food delayed absorption up to 4 hours or longer

Protein binding: 96.3%

Metabolism: Hepatic via CYP3A and 2C19 to inactive metabolites; CYP2C19 exhibits a known genetic polymorphism due to its deficiency in some subpopulations (3% to 5% of Caucasians and 17% to 20% of Asians) which results in slower metabolism

Bioavailability: Tablet: ~52%

Half-life elimination (dose dependent):

Children ≤11 years: 2.5 hours

Children ≥12 years and Adolescents: 20 mg tablet: 0.97 ± 0.19 hours (James 2007)

Adults: 1 to 2 hours

Time to peak, plasma:

Children ≤11 years: Sprinkle capsule: 2 to 4 hours

Children ≥12 years and Adolescents: 20 mg tablet: 4.1 ± 0.45 hours (James 2007)

Adults: Tablet: 2 to 5 hours; Sprinkle capsule: 1 to 6.5 hours

Excretion: Urine (90% primarily as thioether carboxylic acid metabolites); remainder in feces

Pharmacokinetics: Additional Considerations (Adult Data Unless Noted)

Hepatic function impairment: In mild to moderate hepatic impairment, AUC approximately doubled, total clearance decreased to less than half, and C_max increased ~20% (not statistically significant) and elimination half-life was 2- to 3-fold higher.

Older adult: AUC values approximately doubled; C_max increased 60%.

Race/ethnicity: AUCs for Japanese men were 50% to 60% higher.

Brand Names: International

International Brand Names by Country

For country code abbreviations (show table)

(AE) United Arab Emirates: Gasorab | Inrab | Pariet | Rabezole | Ramep | Ulcerbrex;
(AR) Argentina: Pariet | Rabec | Rabeprazol Northia;
(AT) Austria: Pariet | Rabeprazol | Rabeprazol accord | Rabeprazol Actavis | Rabeprazol krka | Rabeprazol sandoz;
(AU) Australia: Apo rabeprazole | Chemmart rabeprazole | Noumed rabeprazole | Parbezol | Pariet | Parzol | Prabez | Rabeprazole actavis | Rabeprazole an | Rabeprazole drla | Rabeprazole generichealth | Rabeprazole mylan | Rabeprazole pfizer | Rabeprazole rbx | Rabeprazole sandoz | Rabeprazole sun | Rabzole | Razit | Stada Rabeprazole | Terry white chemists rabeprazole | Zabep;
(BD) Bangladesh: Acifix | Finix | Gastrazole | Nexrab | Paricel | Profast | Prompton | Rabe | Rabeca | Rabecon | Rabemax | Rabepes | Rabeprol | Rabesec | Rabetac | Rabetem | Rabigut | Rabipep | Rabizol | Rablet | Rabonac | Raboz | Rabprazo | Raha | Rasodium | Rasonix | Rasoz | Razole | Rexiet | Xorel | Zorab;
(BE) Belgium: Pariet | Rabeprazole Teva;
(BF) Burkina Faso: Rabeloc | Rabemac | Rabetar;
(BG) Bulgaria: Acilesol | Pariet | Rabioxin;
(BR) Brazil: Iniparet | Pariet | Rabeprazol sodico;
(CH) Switzerland: Pariet | Rabeprazol mepha | Rabeprazol sandoz;
(CI) Côte d'Ivoire: Fizo | Rabeloc | Rabemac | Rabeprane | Rabeprazol generis | Rabetok;
(CN) China: Aciphex | AN SI FEI | Ding qi er | Ji nuo | Pariet | Rui bo te | Xin wei an | Yu tian qing;
(CO) Colombia: Pariet | Rapoxol;
(CZ) Czech Republic: Noflux | Rapoxol;
(DE) Germany: Pariet | Rabeprazol | Rabeprazol Actavis | Rabeprazol aurobindo | Rabeprazol Heumann | Rabeprazol natrium puren | Rabeprazol puren | Rabeprazol Ratiopharm;
(DO) Dominican Republic: Gasul | Pariet | Rabex | Raizar;
(EC) Ecuador: Pariet | Rabezol;
(EE) Estonia: Pariet | Rabeprazole actavis;
(EG) Egypt: Bepra | Burnaway | Hygigastin | Idizole | Pacredo | Pariet | Rabegerdazole | Rabeprakyrl | Rabeprazole | Rabezole | Rabicid | Syrandrazole | Ulcerostate;
(ES) Spain: Aciphex | Gelbra | Pariet | Rabeprazol Actavis | Rabeprazol Almus | Rabeprazol alter | Rabeprazol Apotex | Rabeprazol aurobindo | Rabeprazol Cinfa | Rabeprazol Combix | Rabeprazol Kern pharma | Rabeprazol krka | Rabeprazol mabo | Rabeprazol mylan | Rabeprazol Normon | Rabeprazol pensa | Rabeprazol Qualigen | Rabeprazol ranbaxy | Rabeprazol Ratio | Rabeprazol sandoz | Rabeprazol Stada | Rabeprazol Tarbis | Rabeprazol Tecnigen | Rabeprazol Teva;
(ET) Ethiopia: Rabeloc | Rabemac | Rabimed;
(FI) Finland: Pariet | Rabeprazol krka | Rabeprazol Navamedic;
(FR) France: Pariet | Rabeprazole actavis | Rabeprazole alter | Rabeprazole arrow | Rabeprazole Biogaran | Rabeprazole cristers | Rabeprazole Dci | Rabeprazole eg labo | Rabeprazole evolugen | Rabeprazole Isomed | Rabeprazole krka | Rabeprazole mylan pharma | Rabeprazole Phr | Rabeprazole ranbaxy | Rabeprazole sandoz | Rabeprazole Teva | Rabeprazole Zentiva | Rabeprazole Zydus;
(GB) United Kingdom: Pariet | Rabeprazole;
(GR) Greece: Aircodos | Beprasyn | Berlex | Medotis | Pariet | Rabeprazole sodium/teva | Rabeprazole/actavis | Raberen/iasis;
(HK) Hong Kong: Nikp rabeprazole | Pariet | Rabeprazole | Rabestad | Rabetra | Rabicid | Rabiswift | Razole;
(HR) Croatia: Ares;
(HU) Hungary: Acilesol | Gelbra | Pariet | Rabegen | Rabeprazol 1a pharma | Rabeprazol Teva | Rabeprazol Zentiva | Rabesim | Rabirep | Rabyprex | Ralic;
(ID) Indonesia: Pariet;
(IE) Ireland: Pariet | Rabeprazole | Rabeprazole krka | Rabeprazole sodium actavis | Rabiclon | Razole;
(IN) India: Above | Acera | Aciless | Acistal | Actsun | Albera | Algibra | Allevrab | Anslag | Arorab | Asalt | Asidrop | Beepraz | Bipra | Bravia | Celerab | Cyra | Daparar | Depump | Diorob | Domol | Drego | Ec rab | Ecorab | Elpizole | Elrab | Emrab | Erb | Erirab | Erzol | Faithrab | Fast | Frab | Gastrazole | Genpraz | Happi | Helirab | Hinrab | Hirabezol | Hyzole | Inrab | Jactorab | Kepreb | LACRIN | Neutracaine | Nura | Nurab | Odirab | Omnisec | Orirab | Parit | Pepcia | Pepraz | Peptard | Pepzera | Ppbest | Prazohext | Prorab | R cid | R Ppi | R prazix | R zet iv | Rab | Rabalkem | Raban | Rabazio | Rabby | Rabcer | Rabec | Rabecom | Rabecool | Rabedal | Rabee | Rabefit | Rabefresh | Rabegard | Rabekind | Rabel | Rabeloc | Rabeloc fast | Rabemac | Rabemax | Rabemed | Rabemon | Rabeoz | Rabepol | Rabepraz | Rabeprim | Rabepro | Rabeprot | Rabepump | Rabequeen | Rabera | Rabesec | Rabest | Rabestar | Rabetac | Rabeteo | Rabeto | Rabewal | Rabexid | Rabexin | Rabextin | Rabeyog | Rabez | Rabez Fr | Rabezol | Rabezox | Rabica | Rabicad | Rabicent | Rabicer | Rabicip | Rabiet | Rabifast | Rabifin | Rabifine | Rabifix | Rabilife | Rabiloz | Rabimak | Rabimax | Rabimed | Rabimond | Rabimor | Rabin | Rabindol | Rabinist | Rabinock | Rabipace | Rabipen | Rabipot | Rabiram | Rabiros | Rabirow | Rabisafe | Rabisent | Rabiset | Rabitab | Rabital | Rabitem | Rabitis | Rabitiv | Rabitoch | Rabitop | Rabium | Rabivel | Rabiwin | Rabizorb | Rablet | Rably | Rabnav | Rabnex | Rabnol | Rabnor | Rabnoz | Raboc | Rabol | Rabona | Rabonik | Raboserv | Rabot | Rabowin | Raboye | Rabozz | Rabset | Rabsig | Rabtic | Raby | Rabzer | Rantac pp | Rantac r | Rapco | Rapeed | Rapirol | Raptac | Ravier | Ravoz | Ravsid | Razo | Razodent | Razogard | Rbp | Rbx | Rbz | Rebocare | Rekool | Repral | Repraz | Rioz | Ripra | Robbie | Robezole | Robowin | Rolant | Roles | Roles SF | Ropraz | Roz R | Rybo | Setright | Siorab | Sirab | Sonirab 20 | Stomeck | Strovo | Superia | Suzol | Themikool | Ulcirab | Ulgo | Unirab | Value | Veloz | Venorab | Walrab | Wokarab | Zebra | Zen-prazole | Zolopep | Zolorab | Zool | Zora | Zuropraz;
(IS) Iceland: Pariet;
(IT) Italy: Akirab | Gelbra | Pariet | Rabeprazolo | Rabeprazolo accord | Rabeprazolo Actavis | Rabeprazolo Doc | Rabeprazolo eg | Rabeprazolo pensa | Rabeprazolo ranbaxy | Rabeprazolo Sandoz | Rabeprazolo tecnigen | Rabeprazolo Zentiva | Rabex | Starab;
(JO) Jordan: Pariet | Rabex;
(JP) Japan: Pariet | Rabeprazole na | Rabeprazole na biomedix | Rabeprazole na sawai | Rabeprazole na zydus;
(KE) Kenya: Barole | Bepra | Inrab | Pariet | Promto | Rabekind | Rabeloc | Rabemac | Rabeque | Rabesta | Rabeto | Rabezol | Rabosec | Rapeed | Raz | Razid | Robort | Rzole | Strirab | Veloz;
(KR) Korea, Republic of: Aprogen rabeprazole | Aukorazole | Belpran | Benpra | Bepzole | Berazol | Borirabe | Celrabe | Cmg Rabeprazole | Daewoong rabeprazole | Drabe | Erlsara | Espra | Glorabe | Inist rabeprazole | Kyongbo rabeprazole | Neo world | Neobat | Newbepra | Newbera | Newrabe | Newrabell | P.i.zole | Pabirazole | Pabizol | Pabizole | Parabezole | Paramet | Pariaton | Pariazole | Pariben | Pariet | Parinazole | Pariva | Pavirazole | Pharvis rabeprazole | Pipirazol | Pipirazole | Pizole | Rabazole | Rabe m | Rabed | Rabefree | Rabegen | Rabehu | Rabekan | Rabekhan | Rabela | Rabemax | Rabemin | Rabena | Rabendazole | Rabenex | Rabenp | Rabentid | Rabeol | Rabeone | Rabepa | Rabepazole | Rabepezole | Rabepia | Rabepine | Rabeplus | Rabepna | Rabepon | Rabepra | Rabepradid | Rabepran | Rabeprazole | Rabeprine | Rabeprizole | Rabepro | Rabeprol | Rabepron | Rabepzole | Raber | Rabera | Rabera m | Raberaton | Raberaz | Raberin | Raberit | Raberon | Raberose | Raberoze | Rabesta | Rabestin | Rabesto | Rabet | Rabeton | Rabetop | Rabetra | Rabetwo | Rabeum | Rabewon | Rabezol | Rabi m | Rabiet | Rabipa | Rabister | Rapezol | Rapies | Rapizole | Raplite | Raprazole | Raprin | Raprizole | Rarabe | Rebe | Reipra | Reprazole | Resprazole | Robedol | Rp rabe | Samsung rabeprazole | Spc rabe | Storabe | Td rabe | Ulcera | Unirabep | Wi rabeprazole | Yurazole;
(KW) Kuwait: Pariet | Ulcerbrex;
(LB) Lebanon: Pariet | Prasolan | Puloros | Rabe tad | Rabec | Rabezol | Rabizec | Rebacip;
(LT) Lithuania: Pariet | Rabeprazole actavis | Yzilan | Zulbex;
(LU) Luxembourg: Pariet | Rabeprazol Ratiopharm;
(LV) Latvia: Pariet | Zulbex;
(MA) Morocco: Ranciphex;
(MX) Mexico: Pariet;
(MY) Malaysia: Pariet | Rabeprazole sandoz | Rabotide;
(NG) Nigeria: Acerid | Acizole | Barole | Chiprazole | Marybazole | Pyrox | Rabefast | Rabelex | Rabepraz | Rabeprazole | Rabesam | Rabezole | Rebizole | Ulcurex | Unozole;
(NL) Netherlands: Pariet | Rabeprazolnatrium | Rabeprazolnatrium actavis | Rabeprazolnatrium krka | Rabeprazolnatrium mylan | Rabeprazolnatrium pch | Rabeprazolnatrium sandoz;
(PE) Peru: Ibp | Pariet | Rabe-gastrin | Rabepramek | Rabium;
(PH) Philippines: Doctra | Mergium | Pariet | Rabeloc | Rabesta | Rabicor | Rapeed | RM Rabeprazole | Uniprazole;
(PK) Pakistan: Acifix | Allicid | Alreb | Apt | Arro | Bepra | Epazole | Eraze | Helirab | Isra | Meta rib | Nilflux | Novipraz | Procone | Promto | Protorib | Rabeadvan | Rabekan | Rabera | Rabesod | Rabetec | Rabezan | Rabicol | Rabimed | Rabin | Rabixin | Rabizole | Rablet | Rabonik | Rabosh | Rabro | Rabz | Rabzole | Ranzot | Rapezol | Rapral | Raprazole | Ravera | Razole | Rebzer | Revolt | Rezz 20 | Xepra | Zechin;
(PL) Poland: Pariet | Zulbex;
(PR) Puerto Rico: Aciphex | Rabeprazole sod | Rabeprazole sodium delayed release;
(PT) Portugal: Pariet | Rabeprazol | Rabeprazol alter | Rabeprazol aurobindo | Rabeprazol azevedos | Rabeprazol basi | Rabeprazol ciclum | Rabeprazol generis | Rabeprazol krka | Rabeprazol Labesfal | Rabeprazol mepha | Rabeprazol mylan | Rabeprazol pentafarma | Rabeprazol pharmakern | Rabeprazol Ratiopharm | Rabeprazol sandoz | Rabeprazol tolife | Rabeprazol Zentiva;
(QA) Qatar: Inrab | Pariet | Rabezole | Ulcerbrex;
(RO) Romania: Relitaz | Zulbex;
(RU) Russian Federation: Bereta | Hirabezol | Noflux | Ontime | Pariet | Rabeloc | Rabeprazole | Rabeprazole obl | Rabeprazole sz | Rabeprazole vertex | Rabiet | Razo | Ulblock | Ulcernil | Zolispan | Zulbex;
(SA) Saudi Arabia: Pariet | Rabezole;
(SE) Sweden: Pariet;
(SG) Singapore: Pariet | Rabeprazole sandoz;
(SK) Slovakia: Noflux | Zulbex;
(TH) Thailand: Pariet | Rabeprazole sandoz;
(TR) Turkey: Pariet | Patril | Prabex | Rabelis | Rabiza | Rabober | Ragi | Raneks | Razogen;
(TW) Taiwan: Genulcer | Pariet | Rabe | Rabett | Sinprazole;
(UA) Ukraine: Barol | Barol 10 | Barol 20 | Geerdin | Pariet | Rabeloc | Rabeprazole | Rabezol | Rabigem | Razo | Razole | Veloz;
(UG) Uganda: Barole | Rabeloc | Rabemac | Rabezol | Rabiza | Rabotide fast | Rabtas | Rapeed | Repraz | Welrab;
(UY) Uruguay: Pariet | Rabec;
(VE) Venezuela, Bolivarian Republic of: Pariet;
(VN) Viet Nam: Anrbe | Apbezo | Beprasan | Bipraso | Cadirabe | Dupraz | Eurorapi | Glazymap | Glovalox | Kazmeto | Martaz | Pawentik | Rabenobe | Rabepagi | Rabofar | Rabupin | Ramprozole | Raxium | Razolmed | Sanrabe | Sitaz | Souzal | Tendirazol;
(ZA) South Africa: Pariet | Rabemed;
(ZM) Zambia: Rabekind | Rabeloc | Veloz

2023 American Geriatrics Society Beers Criteria Update Expert Panel. American Geriatrics Society 2023 updated AGS Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2023;71(7):2052-2081. doi:10.1111/jgs.18372 [PubMed 37139824]
Abraham NS, Hlatky MA, Antman EM, et al. ACCF/ACG/AHA 2010 Expert Consensus Document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. Circulation. 2010;122(24):2619-33. doi:10.1161/CIR.0b013e318202f701 [PubMed 21060077]
Aciphex Delayed-Release tablets (rabeprazole) [prescribing information]. Woodcliff Lake, NJ: Eisai Inc; March 2022.
Aciphex Delayed-Release tablets (rabeprazole) [prescribing information]. Wixom, MI: Waylis Therapeutics LLC; July 2023.
Aciphex tablets (rabeprazole) [prescribing information]. Woodcliff Lake, NJ: Eisai Inc; November 2020.
Aciphex Sprinkle capsules (rabeprazole) [prescribing information]. Englewood, CO: Aytu Therapeutics; December 2020.
Ali RAR, Hassan J, Egan LJ. Review of recent evidence on the management of heartburn in pregnant and breastfeeding women. BMC Gastroenterol. 2022;22(1):219. doi:10.1186/s12876-022-02287-w [PubMed 35508989]
American Society of Anesthesiologists (ASA). Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures: an updated report by the American Society of Anesthesiologists Task Force on preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration. Anesthesiology. 2017;126(3):376-393. doi:10.1097/ALN.0000000000001452 [PubMed 28045707]
Babic Z, Bogdanovic Z, Dorosulic Z, et al. One year treatment of Barrett's oesophagus with proton pump inhibitors (a multi-center study). Acta Clin Belg. 2015;70(6):408-13. doi:10.1080/17843286.2015.1107203 [PubMed 26790552]
Barkun AN, Almadi M, Kuipers EJ, et al. Management of nonvariceal upper gastrointestinal bleeding: guideline recommendations from the International Consensus Group. Ann Intern Med. 2019;171(11):805-822. doi:10.7326/M19-1795 [PubMed 31634917]
Bell AD, Roussin A, Cartier R, et al, “The Use of Antiplatelet Therapy in the Outpatient Setting: Canadian Cardiovascular Society Guidelines,” Can J Cardiol, 2011, 27(Suppl A):1-59. [PubMed 21640290]
Bergsland E. Management and prognosis of the Zollinger-Ellison syndrome (gastrinoma). Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed March 10, 2021.
Bonis PAL, Gupta SK. Treatment of eosinophilic esophagitis. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed October 25, 2021.
Boparai V, Rajagopalan J, Triadafilopoulos G. Guide to the use of proton pump inhibitors in adult patients. Drugs. 2008;68(7):925-947. doi:10.2165/00003495-200868070-00004 [PubMed 18457460]
Boullata JI. Guidebook on Enteral Medication Administration. American Society for Parenteral and Enteral Nutrition; 2019.
Canani RB, Cirillo P, Roggero P, et al, "Therapy With Gastric Acidity Inhibitors Increases the Risk of Acute Gastroenteritis and Community-Acquired Pneumonia in Children," Pediatrics, 2006, 117(5):e817-20. [PubMed 16651285]
Chalasani NP, Hayashi PH, Bonkovsky HL, et al. ACG Clinical Guideline: the diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol. 2014;109(7):950-966. [PubMed 24935270]
Chey WD, Howden CW, Moss SF, et al. ACG clinical guideline: treatment of Helicobacter pylori infection. Am J Gastroenterol. 2024;119(9):1730-1753. doi:10.14309/ajg.0000000000002968 [PubMed 39626064]
Chey WD, Leontiadis GI, Howden CW, Moss SF. ACG clinical guideline: treatment of Helicobacter pylori infection. Am J Gastroenterol. 2017;112(2):212-239. doi:10.1038/ajg.2016.563 [PubMed 28071659]
Chey WD, Wong BC; Practice Parameters Committee of the American College of Gastroenterology. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 2007;102(8):1808-1825. doi:10.1111/j.1572-0241.2007.01393.x [PubMed 17608775]
Choi A, Noh Y, Jeong HE, et al. Association between proton pump inhibitor use during early pregnancy and risk of congenital malformations. JAMA Netw Open. 2023;6(1):e2250366. doi:10.1001/jamanetworkopen.2022.50366 [PubMed 36626173]
Cloud ML, Enas N, Humphries TJ, Bassion S. Rabeprazole in treatment of acid peptic diseases: results of three placebo-controlled dose-response clinical trials in duodenal ulcer, gastric ulcer, and gastroesophageal reflux disease (GERD). The Rabeprazole Study Group. Dig Dis Sci. 1998;43(5):993-1000. doi:10.1023/a:1018822532736 [PubMed 9590413]
Cockayne SE, Glet RJ, Gawkrodger DJ, et al, “Severe Erythrodermic Reactions to the Proton Pump Inhibitors Omeprazole and Lansoprazole,” Br J Dermatol,1999, 141(1):173-5. [PubMed 10417548]
Das S. NSAIDs (including aspirin): Primary prevention of gastroduodenal toxicity. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed October 13, 2021.
de Jager CP, Wever PC, Gemen EF, et al, “Proton Pump Inhibitor Therapy Predisposes to Community-Acquired Streptococcus pneumoniae Pneumonia,” Aliment Pharmacol Ther, 2012, 36(10):941-9. [PubMed 23034135]
Dekkers CP, Beker JA, Thjodleifsson B, Gabryelewicz A, Bell NE, Humphries TJ. Comparison of rabeprazole 20 mg vs. omeprazole 20 mg in the treatment of active gastric ulcer--a European multicentre study. The European Rabeprazole Study Group. Aliment Pharmacol Ther. 1998;12(8):789-795. doi:10.1046/j.1365-2036.1998.00373.x [PubMed 9726393]
Dewan B, Philipose N. Lafutidine 10 mg versus Rabeprazole 20 mg in the Treatment of Patients with Heartburn-Dominant Uninvestigated Dyspepsia: A Randomized, Multicentric Trial. Gastroenterol Res Pract. 2011;2011:640685. doi:10.1155/2011/640685 [PubMed 21687618]
Dunbar K, Yadlapati R, Konda V. Heartburn, nausea, and vomiting during pregnancy. Am J Gastroenterol. 2022;117(10S):10-15. doi:10.14309/ajg.0000000000001958 [PubMed 36194028]
Dvořáčková E, Pilková A, Matoulek M, Slanař O, Hartinger JM. Bioavailability of orally administered drugs after bariatric surgery. Curr Obes Rep. 2024;13(1):141-153. doi:10.1007/s13679-023-00548-7 [PubMed 38172482]
Eichenwald EC; Committee on Fetus and Newborn. Diagnosis and management of gastroesophageal reflux in preterm infants. Pediatrics. Published online July 2, 2018. [PubMed 29915158]
Expert opinion. Senior Enteral Feeding Tube Editorial Team: Joseph I. Boullata, PharmD, RPh, CNS-S, FASPEN, FACN; Peggi A. Guenter, PhD, RN, FASPEN; Kathleen Gura, PharmD, BCNSP, FASHP, FASPEN, FPPA, FMSHP; Mark G. Klang, MS, RPh, BCNSP, PhD, FASPEN; Linda Lord, NP, ACNP-BC, CNSC, FASPEN; Lucas E. Orth, PharmD, BCPPS; Russel J. Roberts, PharmD, BCCCP, FCCM.
Fallone CA, Chiba N, van Zanten SV, et al. The Toronto consensus for the treatment of Helicobacter pylori infection in adults. Gastroenterology. 2016;151(1):51-69.e14. doi:10.1053/j.gastro.2016.04.006 [PubMed 27102658]
Fass R. Approach to refractory gastroesophageal reflux disease in adults. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed March 9, 2021.
Friedman LS. NSAIDs (including aspirin): Treatment and secondary prevention of gastroduodenal toxicity. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed December 26, 2023.
García González D, Martín-Suárez A, Salvador Sánchez JJ, Sánchez Serrano JÁ, Calvo MV. Medication delivery errors in outpatients with percutaneous endoscopic gastrostomy: effect on tube feeding replacement. Sci Rep. 2023;13(1):21727. doi:10.1038/s41598-023-48629-w [PubMed 38066068]
Haastrup P, Paulsen MS, Begtrup LM, Hansen JM, Jarbøl DE. Strategies for discontinuation of proton pump inhibitors: a systematic review. Fam Pract. 2014;31(6):625-630. doi:10.1093/fampra/cmu050 [PubMed 25192903]
Haddad I, Kierkus J, Tron E, et al. Maintenance of efficacy and safety of rabeprazole in children with endoscopically proven GERD. J Pediatr Gastroenterol Nutr. 2014;58(4):510-517. [PubMed 24164904]
Hirano I, Chan ES, Rank MA, et al; AGA Institute Clinical Guidelines Committee; Joint Task Force on Allergy-Immunology Practice Parameters. AGA Institute and the Joint Task Force on Allergy-Immunology Practice Parameters clinical guidelines for the management of eosinophilic esophagitis. Gastroenterology. 2020;158(6):1776-1786. doi:10.1053/j.gastro.2020.02.038 [PubMed 32359562]
Holmes DR, Sorajja P. Gastrointestinal bleeding in patients undergoing percutaneous coronary intervention. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed March 9, 2021.
Hu Q, Sun TT, Hong J, Fang JY, Xiong H, Meltzer SJ. Proton pump inhibitors do not reduce the risk of esophageal adenocarcinoma in patients with Barrett's esophagus: a systematic review and meta-analysis. PLoS One. 2017;12(1):e0169691. doi:10.1371/journal.pone.0169691 [PubMed 28072858]
Hussain S, Kierkus J, Hu P, et al. Safety and efficacy of delayed release rabeprazole in 1- to 11-month-old infants with symptomatic GERD. J Pediatr Gastroenterol Nutr. 2014;58(2):226-236. doi:10.1097/MPG.0000000000000195 [PubMed 24121146]
Hussain S, Singh A, Antony B, et al. Proton pump inhibitors use and risk of preeclampsia: a meta- analysis. J Clin Med. 2022;11(16):4675. doi:10.3390/jcm11164675 [PubMed 36012913]
Ibanez B, James S, Agewall S, et al; ESC Scientific Document Group. 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119-177. doi:10.1093/eurheartj/ehx393 [PubMed 28886621]
Iwakiri R, Higuchi K, Kato M, et al. Randomised clinical trial: prevention of recurrence of peptic ulcers by rabeprazole in patients taking low-dose aspirin. Aliment Pharmacol Ther. 2014;40(7):780-795. doi: 10.1111/apt.12907. [PubMed 25100080]
Iwakiri R, Tominaga K, Furuta K, et al. Randomised clinical trial: rabeprazole improves symptoms in patients with functional dyspepsia in Japan. Aliment Pharmacol Ther. 2013;38(7):729-740. doi: 10.1111/apt.12444. [PubMed 23957383]
James L, Walson P, Lomax K, et al. Pharmacokinetics and tolerability of rabeprazole sodium in subjects aged 12 to 16 years with gastroesophageal reflux disease: an open-label, single- and multiple-dose study. Clin Ther. 2007; 29(9):2082-2092. [PubMed 18035206]
Jones NL, Koletzko S, Goodman K, et al. Joint ESPGHAN/NASPGHAN guidelines for the management of Helicobacter pylori in children and adolescents (update 2016). J Pediatr Gastroenterol Nutr. 2017;64(6):991-1003. [PubMed 28541262]
Kahrilas PJ. Medical management of gastroesophageal reflux disease in adults. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed March 9, 2021.
Kahrilas PJ, Shaheen NJ, Vaezi MF, et al, “American Gastroenterological Association Medical Position Statement on the Management of Gastroesophageal Reflux Disease,” Gastroenterology, 2008, 135(4):1383-91. [PubMed 18789939]
Kastelein F, Spaander MC, Steyerberg EW, et al; ProBar Study Group. Proton pump inhibitors reduce the risk of neoplastic progression in patients with Barrett's esophagus. Clin Gastroenterol Hepatol. 2013;11(4):382-388. doi:10.1016/j.cgh.2012.11.014 [PubMed 23200977]
Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013;108(3):308-328. doi:10.1038/ajg.2012.444 [PubMed 23419381]
Kim HK, Kim JS, Kim TH, et al. Effect of high-dose oral rabeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. Gastroenterol Res Pract. 2012;2012:317125. doi: 10.1155/2012/317125. [PubMed 23049546]
Kim J, Blackett JW, Jodorkovsky D. Strategies for Effective Discontinuation of Proton Pump Inhibitors. Curr Gastroenterol Rep. 2018;20(6):27. doi: 10.1007/s11894-018-0632-y. [PubMed 29767318]
Kimko H, Thyssen A, Mould DR, Mannaert E, Treem WR. Helicobacter pylori treatment in children: defining a dose for rabeprazole as a part of a triple therapy regimen. J Clin Pharmacol. 2015;55(5):592-600. [PubMed 25639255]
Klang MG. Developing guidance for feeding tube administration of oral medications. JPEN J Parenter Enteral Nutr. 2023;47(4):519-540. doi:10.1002/jpen.2490 [PubMed 36847617]
Laine L, Barkun AN, Saltzman JR, Martel M, Leontiadis GI. ACG clinical guideline: upper gastrointestinal and ulcer bleeding. Am J Gastroenterol. 2021;116(5):899-917. doi:10.14309/ajg.0000000000001245 [PubMed 33929377]
Lam JR, Schneider JL, Zhao W, Corley DA. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. JAMA. 2013;310(22):2435-2422. [PubMed 24327038]
Lanza FL, Chan FK, Quigley EM; Practice Parameters Committee of the American College of Gastroenterology. Guidelines for prevention of NSAID-related ulcer complications. Am J Gastroenterol. 2009;104(3):728-738. doi:10.1038/ajg.2009.115 [PubMed 19240698]
Laserna-Mendieta EJ, Casabona S, Guagnozzi D, et al; EUREOS EoE CONNECT research group. Efficacy of proton pump inhibitor therapy for eosinophilic oesophagitis in 630 patients: results from the EoE connect registry. Aliment Pharmacol Ther. 2020;52(5):798-807. doi:10.1111/apt.15957 [PubMed 32677040]
Lazarus B, Chen Y, Wilson FP, et al. Proton pump inhibitor use and the risk of chronic kidney disease. JAMA Intern Med. 2016:238-246. [PubMed 26752337]
Levine GN, Bates ER, Blankenship JC, et al, “2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions,” Circulation, 2011, 124(23):e574-651. [PubMed 22064601]
Li X-Q, Anderson TB, Ahlstrom M, et al, “Comparison of Inhibitory Effects of the Proton Pump-Inhibiting Drugs Omeprazole, Esomeprazole, Lansoprazole, Pantoprazole, and Rabeprazole on Human Cytochrome P450 Activities,” Drug Metab Disp, 2004, 32(8):821-827. [PubMed 15258107]
Lightdale JR, Gremse DA; Section on Gastroenterology, Hepatology, and Nutrition. Gastroesophageal reflux: management guidance for the pediatrician. Pediatrics. 2013;131(5):e1684-e1695. doi:10.1542/peds.2013-0421 [PubMed 23629618]
Lin KJ, Hernández-Díaz S, García Rodríguez LA. Acid suppressants reduce risk of gastrointestinal bleeding in patients on antithrombotic or anti-inflammatory therapy. Gastroenterology. 2011;141(1):71-79. doi:10.1053/j.gastro.2011.03.049 [PubMed 21458456]
Longstreth GF, Lacy BE. Approach to the adult with dyspepsia. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed June 20, 2022.
Lucendo AJ, Arias Á, Molina-Infante J. Efficacy of proton pump inhibitor drugs for inducing clinical and histologic remission in patients with symptomatic esophageal eosinophilia: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2016;14(1):13-22.e1. doi:10.1016/j.cgh.2015.07.041 [PubMed 26247167]
Malchodi L, Wagner K, Susi A, Gorman G, Hisle-Gorman E. Early acid suppression therapy exposure and fracture in young children. Pediatrics. 2019;144(1):e20182625. [PubMed 31175146]
Moayyedi PM, Lacy BE, Andrews CN, Enns RA, Howden CW, Vakil N. ACG and CAG clinical guideline: management of dyspepsia. Am J Gastroenterol. 2017;112(7):988-1013. doi:10.1038/ajg.2017.154 [PubMed 28631728]
Morocutti A, Merrouche M, Bjaaland T, Humphries T, Mignon M. An open-label study of rabeprazole in patients with Zollinger-Ellison syndrome or idiopathic gastric acid hypersecretion. Aliment Pharmacol Ther. 2006;24(10):1439-1444. doi:10.1111/j.1365-2036.2006.03137.x [PubMed 17081164]
Natsch S, Vinks MH, Voogt AK, et al, “Anaphylactic Reactions to Proton-Pump Inhibitors,” Ann Pharmacother, 2000, 34(4):474-6. [PubMed 10772433]
Nishina K, Mikawa K, Takao Y, Shiga M, Maekawa N, Obara H. A comparison of rabeprazole, lansoprazole, and ranitidine for improving preoperative gastric fluid property in adults undergoing elective surgery. Anesth Analg. 2000;90(3):717-721. doi:10.1097/00000539-200003000-00038 [PubMed 10702463]
Nylund CM, Eide M, Gorman GH. Association of Clostridium difficile infections with acid suppression medications in children. J Pediatr. 2014;165(5):979-984. [PubMed 25112692]
Paoluzi P, Iacopini F, Crispino P, et al, “2-Week Triple Therapy for Helicobacter pylori Infection is Better Than 1-Week in Clinical Practice: a Large Prospective Single-Center Randomized Study,” Helicobacter, 2006, 11(6):562-8. [PubMed 17083378]
Peron A, Ripoche E, Picot C, Ajiji P, Cucherat M, Cottin J. Use of proton pump inhibitors during pregnancy: a systematic review and meta-analysis of congenital malformations. Reprod Toxicol. 2023;119:108419. doi:10.1016/j.reprotox.2023.108419 [PubMed 37269915]
Philpott H, Nandurkar S, Royce SG, Thien F, Gibson PR. A prospective open clinical trial of a proton pump inhibitor, elimination diet and/or budesonide for eosinophilic oesophagitis. Aliment Pharmacol Ther. 2016;43(9):985-993. doi:10.1111/apt.13576 [PubMed 26939578]
Pinto-Sanchez MI, Yuan Y, Bercik P, Moayyedi P. Proton pump inhibitors for functional dyspepsia. Cochrane Database Syst Rev. 2017;3:CD011194. doi: 10.1002/14651858.CD011194.pub2. [PubMed 28271513]
Puig I, Calzado S, Suárez D, Sánchez-Delgado J, López S, Calvet X. Meta-analysis: comparative efficacy of H2-receptor antagonists and proton pump inhibitors for reducing aspiration risk during anaesthesia depending on the administration route and schedule. Pharmacol Res. 2012;65(4):480-490. doi:10.1016/j.phrs.2012.01.005 [PubMed 22289674]
Ramakrishnan A, Katz PO. Pharmacologic management of gastroesophageal reflux disease. Curr Treat Options Gastroenterol. 2002;5(4):301-310. doi:10.1007/s11938-002-0053-7 [PubMed 12095478]
Refer to manufacturer's labeling.
Ren P, Cui M, Anand O, et al. In vitro approaches to support bioequivalence and substitutability of generic proton pump inhibitors via nasogastric tube administration. AAPS J. 2017;19(6):1593-1599. doi:10.1208/s12248-017-0137-x [PubMed 28879628]
Rosen R, Vandenplas Y, Singendonk M, et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2018;66(3):516-554. [PubMed 29470322]
Saltzman JR. Overview of the treatment of bleeding peptic ulcers. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed June 6, 2022.
Sanuki T, Fujita T, Kutsumi H, et al; Care Study Group. Rabeprazole reduces the recurrence risk of peptic ulcers associated with low-dose aspirin in patients with cardiovascular or cerebrovascular disease: a prospective randomized active-controlled trial. J Gastroenterol. 2012;47(11):1186-1197. doi: 10.1007/s00535-012-0588-x. [PubMed 22526273]
Shah SC, Kao JY. Treatment of Helicobacter pylori infection in adults. Connor RF, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed April 15, 2025.
Shaheen NJ, Falk GW, Iyer PG, Gerson LB; American College of Gastroenterology. ACG clinical guideline: diagnosis and management of Barrett's esophagus. Am J Gastroenterol. 2016;111(1):30-50. doi:10.1038/ajg.2015.322 [PubMed 26526079]
Spechler SJ. Barrett's esophagus: surveillance and management. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed March 9, 2021.
Talley NJ and Vakil N, “Practice Parameters Committee of the American College of Gastroenterology. Guidelines for the Management of Dyspepsia,” Am J Gastroenterol, 2005, 100(10):2324-37. [PubMed 16181387]
Tamura A, Murakami K, Kadota J; OITA-GF Study Investigators. Prevalence and independent factors for gastroduodenal ulcers/erosions in asymptomatic patients taking low-dose aspirin and gastroprotective agents: the OITA-GF study. QJM. 2011;104(2):133-139. doi:10.1093/qjmed/hcq169 [PubMed 20870780]
Thélin CS, Richter JE. Review article: the management of heartburn during pregnancy and lactation. Aliment Pharmacol Ther. 2020;51(4):421-434. doi:10.1111/apt.15611 [PubMed 31950535]
Turco R, Martinelli M, Miele E, et al. Proton pump inhibitors as a risk factor for paediatric Clostridium difficile infection. Aliment Pharmacol Ther. 2010;31(7):754-759. [PubMed 20047577]
Uesugi T, Mikawa K, Nishina K, Morikawa O, Takao Y, Obara H. The efficacy of lafutidine in improving preoperative gastric fluid property: a comparison with ranitidine and rabeprazole. Anesth Analg. 2002;95(1):144-147, table of contents. doi:10.1097/00000539-200207000-00025 [PubMed 12088958]
Vakil NB. Approach to refractory peptic ulcer disease. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed March 10, 2021c.
Vakil NB. Overview of complications of peptic ulcer disease. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed March 9, 2021a.
Vakil NB. Peptic ulcer disease: treatment and secondary prevention. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed March 10, 2021b.
Vazquez-Elizondo G, Ngamruengphong S, Khrisna M, Devault KR, Talley NJ, Achem SR. The outcome of patients with oesophageal eosinophilic infiltration after an eight-week trial of a proton pump inhibitor. Aliment Pharmacol Ther. 2013;38(10):1312-1319. doi:10.1111/apt.12513 [PubMed 24117619]
Verhaegh BP, de Vries F, Masclee AA, et al. High risk of drug-induced microscopic colitis with concomitant use of NSAIDs and proton pump inhibitors. Aliment Pharmacol Ther. 2016;43(9):1004-1013. doi:10.1111/apt.13583 [PubMed 26956016]
Wang YH, Wintzell V, Ludvigsson JF, Svanström H, Pasternak B. Association between proton pump inhibitor use and risk of fracture in children. JAMA Pediatr. Published online March 16, 2020. [PubMed 32176276]
Wolfe MM. Proton pump inhibitors: overview of use and adverse effects in the treatment of acid related disorders. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed March 9, 2021.
Wolfe MM, Sachs G. Acid suppression: optimizing therapy for gastroduodenal ulcer healing, gastroesophageal reflux disease, and stress-related erosive syndrome. Gastroenterology. 2000;118(2 suppl 1):S9-S31. doi:10.1016/s0016-5085(00)70004-7 [PubMed 10868896]
Yachimski P, Maqbool S, Bhat YM, Richter JE, Falk GW, Vaezi MF. Control of acid and duodenogastroesophageal reflux (DGER) in patients with Barrett's esophagus. Am J Gastroenterol. 2015;110(8):1143-1148. doi:10.1038/ajg.2015.161 [PubMed 26032153]

Topic 13098 Version 553.0

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Rabeprazole: Pediatric drug information