Risk of breast cancer overall and tumor subtypes associated with protein-truncating variants in 34 genes in population-based studies

Shown are odds ratios and 95% CIs for breast cancer overall (Panel A), ER-positive breast cancer (Panel B), and ER-negative breast cancer (Panel C) associated with protein-truncating variants in 34 genes. The genes are listed in order of decreasing estimated odds ratios for breast cancer overall.