Complications of blood product transfusions by timing of presentation

Acute (minutes to hours)	Delayed/long-term (days to weeks)
Immune	Immune
Acute hemolytic reaction	Delayed hemolytic reaction
Febrile non-hemolytic reaction	Post-transfusion purpura
Allergic reaction/anaphylactic reaction	Immune sensitization
Transfusion related acute lung injury (TRALI)	Transfusion associated graft versus host disease
Transfusion related immunomodulation (TRIM)
Non-immune	Non-immune
Transfusion associated circulatory overload (TACO)	Transmission of sub-acute or chronic infection (eg, hepatitis A, B, or C, HIV, cytomegalovirus [CMV], malaria)
Transfusion transmitted bacterial infection/transfusion associated sepsis	Iron overload
Metabolic complications (eg, citrate toxicity, hypocalcemia, hyperkalemia, hypothermia)
Coagulopathy

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