Initial management of paroxysmal nocturnal hemoglobinuria

Diagnosis of PNH is based on absence or marked reduction of cell surface CD55/CD59 on two peripheral blood lineages by flow cytometry and FLAER. Refer to related UpToDate material for details of criteria for PNH diagnosis and severe BMF syndrome, PNH-associated clinical findings, supportive care, other aspects of PNH management, eligibility for allogeneic HCT, and management of BMF.