Infigratinib: Patient drug information

What is this drug used for?

It is used to treat bile duct cancer.

What do I need to tell my doctor BEFORE I take this drug?

If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
If you are taking any of these drugs: Dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, or rabeprazole.
If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with this drug, like some other drugs used for HIV or certain drugs used for seizures, infection, or stomach or bowel problems. There are many drugs that must not be taken with this drug.
If you are breast-feeding. Do not breast-feed while you take this drug or for 1 month after your last dose.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
Have your blood work checked and eye exams as you have been told by your doctor.
It is common to have dry eyes with this drug. Artificial tears, lubricant eye gels, or other products may be used to prevent or treat dry eyes. If you have questions, talk with the doctor or pharmacist.
Avoid grapefruit and grapefruit juice.
It is common to have high phosphate levels in the blood with this drug. Sometimes, this can be severe and can lead to certain health problems. If you have questions, talk with the doctor.
High triglyceride levels have happened with this drug. Tell your doctor if you have ever had high triglyceride levels.
This drug may cause harm to an unborn baby or loss of an unborn baby. A pregnancy test will be done before you start this drug to show that you are NOT pregnant.
If you may become pregnant, you must use birth control while taking this drug and for some time after the last dose. Ask your doctor how long to use birth control. If you get pregnant, call your doctor right away.
If your sex partner may get pregnant, you must use birth control while taking this drug and for some time after the last dose. Ask your doctor how long to use birth control. If your partner gets pregnant, call the doctor right away.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
Signs of electrolyte problems like mood changes; confusion; muscle pain, cramps, or spasms; weakness; shakiness; change in balance; an abnormal heartbeat; seizures; loss of appetite; or severe upset stomach or throwing up.
Blurred eyesight, seeing flashes of light or black spots, or any other changes in eyesight.
Redness or irritation of the palms of hands or soles of feet.
Swelling.
Numbness or tingling around the mouth.
Fever, chills, or sore throat; any unexplained bruising or bleeding; or feeling very tired or weak.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
Hair loss.
Dry mouth, skin, or eyes.
Mouth irritation or mouth sores.
Eyelash changes.
Change in nails.
Constipation.
Stomach pain.
Feeling tired or weak.
Joint pain.
Pain in arms or legs.
Change in taste.
Headache.
Nosebleed.
Weight loss.
Diarrhea, throwing up, upset stomach, and decreased appetite are common with this drug. If these happen, talk with your doctor about ways to lower these side effects. Call your doctor right away if any of these effects bother you, do not get better, or are severe.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.
Take this drug on an empty stomach. Take at least 1 hour before or 2 hours after eating.
Swallow whole. Do not chew, break, crush, or dissolve.
Take with a full glass of water.
Take this drug at the same time of day.
There may be days when you will not take this drug.
Do not take cimetidine, famotidine, nizatidine, or ranitidine at the same time as this drug. Take this drug at least 2 hours before or 10 hours after taking these drugs.
Do not take antacids within 2 hours before or 2 hours after taking this drug.
Keep taking this drug as you have been told by your doctor or other health care provider, even if you feel well.
If you throw up after taking a dose, do not repeat the dose. Take your next dose at your normal time.

What do I do if I miss a dose?

Take a missed dose as soon as you think about it.
If it has been 4 hours or more since the missed dose, skip the missed dose and go back to your normal time.
Do not take 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

Store at room temperature in a dry place. Do not store in a bathroom.
Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

General drug facts

If your symptoms or health problems do not get better or if they become worse, call your doctor.
Do not share your drugs with others and do not take anyone else's drugs.
Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider's examination and assessment of a patient's specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.

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Infigratinib: Patient drug information