Risk stratification for pediatric hepatoblastoma^[1]

Risk category	PRETEXT group	PRETEXT annotation factors other than distant metastases	Distant metastases	Age (years)	Resected initially?	Serum AFP (ng/mL)
Very low	I	Absent	Absent	Any	Yes	Any
Very low	II	Absent	Absent	<8	Yes	>100
Low	I	Absent	Absent	Any	No	Any
	II	Absent	Absent	<8	No	>100
	III	Absent	Absent	<8	+/–	>1000
Intermediate	I	Present	Absent	<8	+/–	Any
	II	Present	Absent	<8	+/–	>100
	III	Present	Absent	<8	+/–	>1000
	III	+/–	Absent	<8	+/–	101 to 1000
	IV	+/–	Absent	<3	+/–	>100
High	I	Present	Absent	≥8	+/–	Any
	I	+/–	Absent	Any	+/–	Any
	II	+/–	Absent	<8	+/–	≤100
	II	+/–	Absent	≥8	+/–	Any
	II	+/–	Absent	Any	+/–	Any
	III	+/–	Absent	<8	+/–	≤100
	III	+/–	Absent	≥8	+/–	Any
	III	+/–	Absent	Any	+/–	Any
	IV	+/–	Absent	<3	+/–	≤100
	IV	+/–	Absent	≥3	+/–	Any
	Any	+/–	Present	Any	+/–	Any

PRETEXT: pretreatment extent of disease; AFP: alpha-fetoprotein.

Reference:

Meyers RL, Maibach R, Hiyama E, et al. Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration. Lancet Oncol 2017; 18:122.

Graphic 131908 Version 1.0

Risk stratification for pediatric hepatoblastoma[1]