Initial treatment of high-grade gastroenteropancreatic neuroendocrine neoplasms

This algorithm applies to neoplasms arising in the digestive tract with neuroendocrine differentiation and a high proliferative rate (Ki-67 index >20%).

NEC: neuroendocrine carcinoma; NET: neuroendocrine tumor; G3: high-grade; CRT: chemoradiotherapy; FOLFOX: fluorouracil plus leucovorin and oxaliplatin.

* Locoregionally advanced = T4 or node-positive disease; for selected cases outside of the esophagus and distal anorectum, resection might be considered after initial neoadjuvant therapy.

¶ In some cases, trimodality therapy (resection, chemoradiotherapy, systemic platinum-based chemotherapy) may be the most appropriate option for patients with a high risk for recurrence.

Graphic 132086 Version 3.0

خرید پکیج

Initial treatment of high-grade gastroenteropancreatic neuroendocrine neoplasms