Alpelisib dose reduction guidelines for adverse reactions*

Alpelisib dose level	Dose and schedule	Number and strength of tablets
Starting dose	300 mg once daily	Two 150 mg tablets
First-dose reduction	250 mg once daily	One 200 mg tablet and one 50 mg tablet
Second-dose reduction	200 mg once daily^¶	One 200 mg tablet

* Only one dose reduction is permitted for pancreatitis.
¶ If further dose reduction below 200 mg once daily is required, discontinue alpelisib.

Reproduced from: Alpelisib tablets. United States Prescribing Information. US National Library of Medicine. Available at: accessdata.fda.gov/drugsatfda_docs/label/2021/212526Orig1s004lbl.pdf (Accessed on July 23, 2021).

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