ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : -81 مورد

Loci linked to psoriatic arthritis from association studies

Loci linked to psoriatic arthritis from association studies
Gene Study Cases (n) Control Odds ratio P value
Cytokines
IL-2/IL-21 Liu Y, et al[1] 576 480 1.37 0.002
IL-12B Liu Y, et al[1] 576 480 1.1 0.0013
Hüffmeier U, et al[2] 748 937 1.5 4.72×10–7
Hüffmeier U, et al[2] 748 937 1.48 2.1×10–5
IL-13 (2 SNPs) Bowes J, et al[3] 1057 778 1.27 to 1.33 6.1 to 8×10–5
IL-23A Eirís N, et al[4] 48 167 3.04 0.02
IL-23R Stuart PE, et al[5] 1430 1417 1.29 2.5×10–12
Hüffmeier U, et al[2] 748 937 1.59 0.002
TNF Reich K, et al[6] 375 376 1.96 0.0025
MHC class 1
HLA-B27 Winchester R, et al[7] 359 1000 3.18 <0.0001
HLA-B cysteine 67 Bowes J, et al[3] 1962 8923 1.62 <6.53×10–14
Amino acid 45 Okada Y, et al[8] 3038 3098 1.46 2.2×10–11
HLA-Cw*0602 Liu Y, et al[1] 576 480 2.4 6.9×10–11
Liu Y, et al[1] 576 480 3.2 1.9×10–10
Cell signaling
PTPN22 Bowes J, et al[9] 1177 2155 1.32 <1.49×10–9
REL Ellinghaus E, et al[10] 535 3432 1.27 1.18×10–8
TRAF3IP2 Ellinghaus E, et al[11] 1919 8037 1.57 4.6×10–12
TNIP1 Nair R, et al[12] 1430 1417 1.78 2×10–14
FBXL19 Stuart PE, et al[5] 1831 2546 1.43 2×10–4
TNFAIP3 Stuart PE, et al[5] 1755 5942 1.2 5.9×10–8
Other
NOS2 Stuart PE, et al[5] 1831 2546 1.19 4×10–11
LCE3C_LCE3b deletion Docampo E, et al[13] 420 450 1.82 0.03
IL: interleukin; SNPs: single-nucleotide polymorphisms; TNF: tumor necrosis factor; MHC: major histocompatibility complex; HLA: human leukocyte antigen.
Adapted by permission from Macmillan Publishers Ltd: Nature Reviews Rheumatology. Nograles KE, Brasington RD, Bowcock AM. New insights into the pathogenesis and genetics of psoriatic arthritis. Nat Clin Pract Rheumatol 2009; 5:83. Copyright © 2009. https://www.nature.com/nrrheum/.
References:
  1. Liu Y, Helms C, Liao W, et al. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet 2008; 4:e1000041.
  2. Hüffmeier U, Lascorz J, Böhm B, et al. Genetic variants of the IL-23R pathway: Association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis. J Invest Dermatol 2009; 129:355.
  3. Bowes J, Eyre S, Flynn E, et al. Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris. Ann Rheum Dis 2011; 70:1016.
  4. Eirís N, González-Lara L, Santos-Juanes J, et al. Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus. J Dermatol Sc 2014; 75:167.
  5. Stuart PE, Nair RP, Ellinghaus E, et al. Genome-wide association analysis identifies three psoriasis susceptibility loci. Nat Genet 2010; 42:1000.
  6. Reich K, Hüffmeier U, König IR, et al. TNF polymorphisms in psoriasis: Association of psoriatic arthritis with the promoter polymorphism TNF*-857 independent of the PSORS1 risk allele. Arthritis Rheum 2007; 56:2056.
  7. Winchester R, Minevich G, Steshenko V, et al. HLA associations reveal genetic heterogeneity in psoriatic arthritis and in the psoriasis phenotype. Arthritis Rheum 2012; 64:1134.
  8. Okada Y, Han B, Tsoi LC, et al. Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes. Am J Hum Genet 2014; 95:162.
  9. Bowes J, Loehr S, Budu-Aggrey A, et al. PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus. Ann Rheum Dis 2015; 74:1882.
  10. Ellinghaus E, Stuart PE, Ellinghaus D, et al. Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL. J Invest Dermatol 2012; 132:1133.
  11. Ellinghaus E, Ellinghaus D, Stuart PE, et al. Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat Genet 2010; 42:991.
  12. Nair R, Stuart P, Tsoi L, et al. Genome-wide association analysis of psoriatic arthritis. Br J Dermatol 2014; 171:E111.
  13. Docampo E, Giardina E, Riveira-Muñoz E, et al. Deletion of LCE3C and LCE3B is a susceptibility factor for psoriatic arthritis: a study in Spanish and Italian populations and meta-analysis. Arthritis Rheum 2011; 63:1860.
Graphic 132370 Version 5.0