This pair of photos of a patient with Werner syndrome provides a sense of the rapid progression of Werner syndrome with the acquisition of features of advanced chronologic age over 3 decades, from age 15 (A) to age 48 (B). Note the rounded face; sharp features; graying, thinning, and loss of scalp and eyebrow hair; and thin, atrophic arms.
From: Epstein CJ, Martin GM, Schultz AL, Motulsky AG. Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine (Baltimore) 1966; 45:177. DOI:
10.1097/00005792-196605000-00001. Copyright © 1966. Reproduced with permission from Wolters Kluwer Health. Unauthorized reproduction of this material is prohibited.
