Typical images of lower limbs in Werner syndrome.
(A) Significant hardening and atrophy of the skin and soft tissue are observed below the distal one-third of the lower extremities.
(B) The foot is in relatively good condition, without ulcers yet with a callosity on the heel region.
From: Kubota Y, Takemoto M, Taniguchi T, et al. Management guideline for Werner syndrome 2020. 6. Skin ulcers associated with Werner syndrome: Prevention and non-surgical and surgical treatment. Geriatr Gerontol Int 2021; 21:153.
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