ARIA MRI classification criteria

ARIA type	Radiographic severity
ARIA type	Mild	Moderate	Severe
ARIA-E	FLAIR hyperintensity confined to sulcus and/or cortex/subcortical white matter in one location <5 cm	FLAIR hyperintensity 5 to 10 cm, or more than 1 site of involvement, each measuring <10 cm	FLAIR hyperintensity measuring >10 cm, often with significant subcortical white matter and/or sulcal involvement. One or more separate sites of involvement may be noted.
ARIA-H microhemorrhage	≤4 new incident microhemorrhages	5 to 9 new incident microhemorrhages	10 or more new incident microhemorrhages
ARIA-H superficial siderosis	1 focal area of superficial siderosis	2 focal areas of superficial siderosis	>2 focal areas of superficial siderosis

ARIA: amyloid-related imaging abnormalities; MRI: magnetic resonance imaging; ARIA-E: amyloid-related imaging abnormalities-edema; FLAIR: fluid-attenuated inversion recovery; ARIA-H: amyloid-related imaging abnormalities-hemosiderin deposition.

Reproduced from: Aduhelm (aducanumab-avwa injection) full prescribing information. US Food and Drug Administration. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/761178s000lbl.pdf (Accessed on September 21, 2021).

Graphic 132725 Version 1.0

خرید پکیج

ARIA MRI classification criteria