"Cingulate island" sign on FDG-PET imaging in DLB

(A) ¹⁸F-FDG PET image shows uptake in the posterior cingulate cortex (arrow) in a patient with DLB and relatively reduced uptake in adjacent occipital lobes.

(B) In comparison, there is no disproportionate uptake in the cingulate cortex in a patient with Alzheimer disease.

DLB: dementia with Lewy bodies; FDG-PET: fluorodeoxyglucose-positron emission tomography.

Reproduced with permission from: Lim SM, Katsifis A, Villemagne VL, et al. The 18F-FDG PET cingulate island sign and comparison to 123I-beta-CIT SPECT for diagnosis of dementia with Lewy bodies. J Nucl Med 2009; 50:1638. Copyright © 2009 The Society of Nuclear Medicine and Molecular Imaging. Available at: https://jnm.snmjournals.org/content/50/10/1638.long (Accessed on December 13, 2021).

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"Cingulate island" sign on FDG-PET imaging in DLB