Distinguishing characteristics between PE/HELLP and TTP

	Timing related to gestational age (weeks)
	<10	10-19	20-24	25-29	30-34	≥35	Postpartum
PE/HELLP (n = 818)	0	1 (0.1%)	9 (1%)	46 (6%)	163 (20%)	599 (73%)	0
Immune TTP (n = 22)	2 (9%)	4 (18%)	4 (18%)	4 (18%)	2 (9%)	2 (9%)	4 (18%)
Hereditary TTP (n = 10)	0	2 (20%)	0	3 (30%)	2 (20%)	3 (30%)	0
	Platelet count (per microL) at time of occurrence
	>100,000	80,000-99,000	60,000-79,000	30,000-59,000	10,000-29,000	<10,000
PE/HELLP (n = 838)	745 (89%)	32 (4%)	26 (3%)	25 (3%)	9 (1%)	1 (0.1%)
Immune TTP (n = 90)	1 (1%)	0	2 (2%)	1 (1%)	46 (51%)	40 (44%)

Distinction between PE/HELLP and TTP is important for management; refer to UpToDate for details. In addition to these features, other key distinguishing features include increased blood pressure in PE/HELLP and increased liver synthetic tests in HELLP. There is no specific diagnostic test for PE/HELLP. ADAMTS13 activity <10% is confirmatory for TTP.

PE/HELLP: preeclampsia with severe features-eclampsia/hemolysis, elevated liver function tests, and low platelets continuum; HELLP: hemolysis, elevated liver function tests, and low platelets; TTP: thrombotic thrombocytopenic purpura.

Data from: Perez Botero J, Reese JA, George JN, McIntosh JJ. Severe thrombocytopenia and microangiopathic hemolytic anemia in pregnancy: A guide for the consulting hematologist. Am J Hematol 2021.

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Distinguishing characteristics between PE/HELLP and TTP