NCI CTCAE v5.0 toxic epidermal necrolysis

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Toxic epidermal necrolysis	–	–	–	Skin sloughing covering ≥30% BSA with associated symptoms (eg, erythema, purpura, or epidermal detachment)	Death
Definition – A disorder characterized by greater than 30% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes.

NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events; BSA: body surface area.

Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed October 13, 2021).

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