Postoperative risk factors for PND

Risk factor	Postoperative delirium	Postoperative NCD/POCD
PACU delirium	Yes	Yes
Postoperative delirium	Yes	Yes
ICU stay	Yes	Yes
Sepsis	Yes	Yes
Uncontrolled pain	Yes	Unknown
Benzodiazepine	Yes	Unknown
Deep ICU sedation	Yes	Unknown
Diphenhydramine	Yes	Unknown
Anticholinergics	Yes	Unknown
Decreased mobilization	Yes	Unknown
Sensory deprivation or overload	Yes	Unknown
Infection	Yes	Unknown
Hypoxia	Yes	Unknown
Anemia	Yes	Unknown

PND: perioperative neurocognitive disorders; NCD: neurocognitive disorders; POCD: postoperative cognitive dysfunction; PACU: post-anesthesia care unit; ICU: intensive care unit.

Graphic 134386 Version 1.0

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