Oral antibiotics for acute colonic diverticulitis in adults

Ciprofloxacin (500 mg every 12 hours) plus metronidazole (500 mg every 8 hours)

Levofloxacin (750 mg once daily) plus metronidazole (500 mg every 8 hours)

Trimethoprim-sulfamethoxazole (1 double-strength tablet [contains sulfamethoxazole 800 mg and trimethoprim 160 mg] every 12 hours) plus metronidazole (500 mg every 8 hours)

Amoxicillin-clavulanate (1 tablet [contains 875 mg amoxicillin and 125 mg clavulanic acid] every 8 hours) or amoxicillin-clavulanate extended-release (2 tablets [each tablet contains 1 g amoxicillin and 62.5 mg clavulanic acid] every 12 hours)

The local antibiogram should be consulted to avoid prescribing a regimen to which bacterial resistance exceeds 10%.
Doses may need to be adjusted for kidney impairment or other factors; refer to Lexicomp drug monographs included within UpToDate for additional details.
The total duration of treatment is 10 to 14 days (inclusive of both IV, if any, and oral antibiotics).

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Oral antibiotics for acute colonic diverticulitis in adults