Tezepelumab: Patient drug information

What is this drug used for?

It is used to treat asthma.
Do not use this drug to treat an asthma attack. Use a rescue inhaler. Talk with your doctor.

What do I need to tell my doctor BEFORE I take this drug?

If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
If you have a parasitic worm infection or other type of infection.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
Call your doctor right away if your breathing problems get worse, if your rescue inhaler does not work as well, or if you need to use your rescue inhaler more often.
Allergic reactions have happened with this drug. Most of the time, allergic reactions happen within hours after this drug was given. Sometimes, they can happen days after this drug was given. Talk with the doctor.
If you are also taking an oral or inhaled steroid, talk with your doctor. Do not stop taking it without talking with your doctor.
Talk with your doctor before getting any vaccines. Use of some vaccines with this drug may either raise the chance of an infection or make the vaccine not work as well.
Some people at high risk for parasite infections have gotten a parasite infection after taking this drug. Your doctor may test your stool to see if you have a parasite infection. Talk with your doctor.
Do not share pen or cartridge devices with another person even if the needle has been changed. Sharing these devices may pass infections from one person to another. This includes infections you may not know you have.
Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
Chest pain.
Shortness of breath.
Feeling very tired or weak.
Dizziness or passing out.
Feeling confused.
Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
Throat irritation.
Joint pain.
Back pain.
Pain, redness, swelling, or other reaction where the injection was given.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.
All products:
It is given as a shot into the fatty part of the skin on the top of the thigh or the belly area.
This drug may be given into the outer area of the upper arm if given by someone else.
Prefilled syringes or pens:
If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
Wash your hands before and after use.
Do not shake.
If stored in a refrigerator, let this drug come to room temperature before using it. This usually takes about 60 minutes. Do not heat this drug. Do not put this drug back in the refrigerator after it has reached room temperature.
Do not use if the solution is cloudy, leaking, or has particles.
This drug is colorless to a faint yellow. Do not use if the solution changes color.
Do not use this drug if it has been dropped or if it is broken.
Do not give into skin within 2 inches (5 cm) of the belly button.
Do not inject through clothes. Do not give into skin that is irritated, bruised, red, scaly, hard, scarred, or damaged.
Move the site where you give the shot with each shot.
Each prefilled pen or syringe is for one use only.
Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.

What do I do if I miss a dose?

Vials:
Call your doctor to find out what to do.
Prefilled syringes or pens:
Take a missed dose as soon as you think about it.
If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
Do not take 2 doses on the same day.

How do I store and/or throw out this drug?

Prefilled syringes or pens:
Store in a refrigerator. Do not freeze.
Store in the original container to protect from light.
Do not use if it has been frozen.
If needed, you may store at room temperature for up to 30 days. Write down the date you take this drug out of the refrigerator. If stored at room temperature and not used within 30 days, throw this drug away.
Protect from heat.
Do not put this drug back in the refrigerator after it has been stored at room temperature.
Vials:
If you need to store this drug at home, talk with your doctor, nurse, or pharmacist about how to store it.
All products:
Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

General drug facts

If your symptoms or health problems do not get better or if they become worse, call your doctor.
Do not share your drugs with others and do not take anyone else's drugs.
Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider's examination and assessment of a patient's specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.

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Tezepelumab: Patient drug information