Initial treatment of dystrophic calcinosis cutis in adults with autoimmune connective tissue disease

Refer to UpToDate topic on the management of calcinosis cutis for information on dosing and treatment duration. Not all patients require treatment for calcinosis cutis. Clinical follow-up without intervention is an option for calcinosis cutis that is asymptomatic, nonprogressive, unassociated with internal involvement, and of minimal concern to the patient.

* Suppression of activity of the associated autoimmune disease is suggested based upon the theory that autoimmune disease-related tissue injury contributes to risk for cutaneous calcification.

¶ Topical or intralesional therapy is impractical for patients with numerous widespread lesions.

Δ Surgical removal is an alternative for discrete, symptomatic areas of calcinosis cutis.

◊ Prominent clinical signs of inflammation include significant erythema, pain, and/or ulceration.

§ Inflammation contributes significantly to the morbidity associated with calcinosis cutis, and limited data suggest the anti-inflammatory effects of these drugs may improve associated symptoms or ulceration.

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Initial treatment of dystrophic calcinosis cutis in adults with autoimmune connective tissue disease