Approach to empiric antimicrobial therapy for outpatient treatment of uncomplicated ABRS in children with no contraindications to penicillin antibiotics

This algorithm is intended for use with UpToDate content on ABRS in children. Inpatient therapy is indicated for patients who have toxic-appearance (eg, lethargy, poor perfusion, cardiorespiratory compromise) and complications or suspected complications, with the possible exception of mild preseptal cellulitis in children older than 1 year. If a pathogen is identified, antimicrobial therapy should be adjusted according to susceptibilities. Refer to relevant UpToDate content for additional information (eg, adverse reactions to penicillin antibiotics, evaluation for complications, treatment of ABRS in children with contraindications to penicillin antibiotics).