Key genes and pathways involved in the pathogenesis of cutaneous squamous cell carcinoma

Gene	Frequency of mutation	Functions
TP53	66%	Canonical tumor suppressor gene, sensor of cellular insults such as DNA damage
NOTCH1/2	36 to 55%	Cell-cell signaling, differentiation
FAT1	30%	Regulator of stemness, epithelial-mesenchymal transition
CDKN2A	35%	Negative regulator of cell cycle progression

DNA: deoxyribonucleic acid.

Graphic 138466 Version 1.0

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