Clinical similarities of fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

Female predominance. In clinic, 60 to 80% female. In general population, twice as common in females.

Age of onset, usually 20 to 50 years.

Symptoms overlap:

Physical and laboratory examination unremarkable.

Common associated disorders:

Precipitating event, viral infection, including COVID-19, physical, emotional trauma
Autonomic nervous system dysfunction
Small fiber neuropathy

COVID-19: coronavirus disease 2019.

Courtesy of Don L Goldenberg, MD.

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