Version May 2024
Plaque psoriasis: Topical: Apply a thin layer to the affected area once daily; the treatment period in clinical trials was up to 12 weeks (Ref).
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Refer to adult dosing.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Adverse reactions reported in adults.
>10%:
Dermatologic: Folliculitis (20%)
Respiratory: Nasopharyngitis (11%)
1% to 10%:
Dermatologic: Contact dermatitis (7%), pruritus (3%)
Infection: Influenza (2%)
Nervous system: Headache (4%)
<1%: Dermatologic: Urticaria
There are no contraindications listed in the manufacturer's labeling.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Cream, External:
Vtama: 1% (60 g) [contains benzoic acid, edetate (edta) disodium, polysorbate 80, propylene glycol]
No
Cream (Vtama External)
1% (per gram): $27.70
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Topical: For topical use only; not for oral, ophthalmic, or intravaginal use. Apply as a thin layer to the affected area. Wash hands after use (unless used for treatment of the hands).
Plaque psoriasis: Treatment of plaque psoriasis in adults.
None known.
There are no known significant interactions.
Adverse events were not observed in animal reproduction studies following SUBQ administration.
It is not known if tapinarof is present in breast milk following topical administration.
According to the manufacturer, the decision to breastfeed during therapy should consider the risk of infant exposure, the benefits of breastfeeding to the infant, and the benefits of treatment to the mother.
Binds to and activates the aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor that regulates cytokine and skin-barrier-protein expression and antioxidant activity (Lebwohl 2021). The specific mechanism of action related to psoriasis treatment is not known (manufacturer's labeling).
Absorption: Minimally absorbed; serum concentrations range from undetectable to 0.9 ± 1.4 ng/mL.
Protein binding: 99% (in vitro).
Metabolism: Hepatic, via multiple pathways (oxidation, glucuronidation, and sulfation) in vitro.
آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
