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Classification of severity of acute SARS-CoV-2 infection in children[1]

Classification of severity of acute SARS-CoV-2 infection in children[1]
Severity classification Description
Tier 1: Mild illness No new or increased* supplemental oxygen requirements
Tier 2: Moderate illness New or increased* requirement for supplemental oxygen via nasal cannula
Tier 3: Severe illness New or increased* requirement for supplemental oxygen via high-flow nasal cannula or noninvasive ventilation
Tier 4: Critical illness Supplemental oxygen via mechanical ventilation or ECMO
This table summarizes the classification of severity of acute SARS-CoV-2 infection in hospitalized children. Other experts may use a different severity classification. Refer to UpToDate content on COVID-19 in children for additional information.

ECMO: extracorporeal membrane oxygenation; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2.

* Increased from baseline requirement.

¶ Continuous or bilevel positive airway pressure.
Reference:
  1. Willis ZI, Oliveira CR, Abzug MJ, et al. Guidance for prevention and management of COVID-19 in children and adolescents: A consensus statement from the Pediatric Infectious Diseases Society Pediatric COVID-19 Therapies Taskforce. J Pediatric Infect Dis Soc 2024; 13:159.
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