ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : -1 مورد

Diagnostic criteria for epilepsy of infancy with migrating focal seizures

Diagnostic criteria for epilepsy of infancy with migrating focal seizures
  Mandatory Alerts Exclusionary
Seizures
  • Focal/multifocal tonic or clonic seizures, with or without subtle behavioral arrest and prominent autonomic features
  • Seizures migrate from one hemisphere or lobe to another clinically
  • Seizure frequency rapidly increases in the first weeks and months, often progressing to status epilepticus
  
  • Myoclonic seizures
EEG
  • Ictal recording shows a migrating pattern (this might be missed if a prolonged video EEG is not performed)
  • Interictal: Multifocal discharges
  • Interictal:
    • Suppression burst pattern prior to medication
    • Single persistent epileptic focus on EEG
    • Hypsarhythmia
  
Age at onset
  • <12 months
  • Onset 6 to 12 months
  
Development at onset  
  • Severe delay prior to seizure onset
  
Neurologic examination  
  • Significant abnormalities on neurologic examination prior to seizure onset
  
Comorbidities
  • Developmental plateauing or regression with frequent seizures
    
Imaging    
  • Abnormal neuroimaging with structural causal lesion
Course of illness
  • Neurodevelopmental delay
  • Seizure freedom
  • Lack of brain atrophy on MRI
  
Is MRI or ictal EEG required for diagnosis?
  • An MRI is required for diagnosis to exclude a causal structural etiology.
  • An ictal EEG may not be required if clinical migration is observed. However, an ictal EEG is strongly recommended to document a migrating pattern.
Syndrome without laboratory confirmation: In resource-limited regions, EIMFS can be diagnosed on clinical observation of seizure migration without EEG or MRI, provided all other clinical mandatory and exclusionary criteria are met
EEG: electroencephalography; MRI: magnetic resonance imaging; EIMFS: epilepsy of infancy with migrating focal seizures.
From: Zuberi SM, Wirrell E, Yozawitz E, et al. ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia 2022; 63:1349. Copyright © 2022 The Authors. Available at: https://onlinelibrary.wiley.com/doi/10.1111/epi.17239 (Accessed on November 11, 2022). Reproduced under the terms of the Creative Commons Attribution License 4.0.
Graphic 139215 Version 1.0