Calculator: Clinical criteria for exudative pleural effusion in adults (Light's criteria with continuous likelihood ratios)

Input

Pleural fluid protein
Serum protein
Pleural fluid LDH
Serum LDH
Upper limit of normal serum LDH
Pre-test suspicion of an exudative effusion		%

Results

Important: Inputs must be complete to perform calculation.


Pleural fluid to serum protein ratio
Pleural fluid to serum LDH ratio
Pleural fluid LDH to upper limit of normal serum LDH ratio
Pre-test odds
Pro ratio LR
LDH ratio LR
LDH proportion of lab limit LR
Post-test odds

Post-test probability		%

Decimal precision

Notes

Please refer to UpToDate topic review on evaluation of pleural effusions for more information.
LDH: lactate dehydrogenase; LR: likelihood ratio; Pro Ratio; protein ratio; PFL: pleural fluid LDH; ULN: upper limit of normal ; SL: serum LDH.

Equations used

Pleural_fluid_to_serum_protein_ratio = Pleural_fluid_protein / Serum_protein

Pleural_fluid_to_serum_LDH_ratio = Pleural_fluid_LDH / Serum_LDH

PFL_to_UNL_SL_ratio = PFL / ULN_SL

Pre-test odds = (Pre-test suspicion of an exudative effusion / 100) / (1 - (Pre-test suspicion of an exudative effusion/100))

Pro_ratio_LR = e^{(13.46*(Pleural_fluid_to_serum_protein_ratio-0.503))}

LDH_ratio_LR = e^{(6.59*(Pleural_fluid_to_serum_LDH_ratio-0.731))}

LDH_proportion_of_lab_limit_LR = e^{(3.83*(PFL_to_UNL_SL_ratio-0.594))}

Post-test odds = Pre-test odds * Pro_ratio_LR * LDH_ratio_LR * LDH_proportion_of_lab_limit_LR

Post-test probability = 100 * Post-test odds / (1 + Post-test odds)

References

Only digits 0 to 9 and a single decimal point (".") are acceptable as numeric inputs. Attempted input of other characters into a numeric field may lead to an incorrect result.

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Topic 139614 Version 3.0

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Calculator: Clinical criteria for exudative pleural effusion in adults (Light's criteria with continuous likelihood ratios)