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Calculator: Clinical criteria for exudative pleural effusion in adults (pleural fluid only-3 criteria with continuous likelihood ratios)


Calculator: Clinical criteria for exudative pleural effusion in adults (pleural fluid only-3 criteria with continuous likelihood ratios)

 
Input
 
Pleural fluid protein  
Pleural fluid LDH  
Pleural fluid cholesterol  
Upper limit of normal serum LDH  
Pre-test suspicion of an exudative effusion   %

 
Results
 
Important: Inputs must be complete to perform calculation.

 
 
Pleural fluid LDH to upper limit of normal serum LDH ratio  
Pre-test odds  
Pleural fluid protein LR  
Pleural fluid cholesterol LR  
LDH proportion of lab limit LR  
Post-test odds  

Post-test probability   %
 
Decimal precision  

 
 

 
Notes
  • PFO3 criteria:
    • If the Pleural fluid protein is >3.0 g/dL [>30 g/L], then an exudate is likely.
    • If the Pleural fluid cholesterol is >55 mg/dL [>1.42 mmol/L], then an exudate is likely.
    • If the Pleural fluid LDH is greater than two-thirds the Upper limit of normal serum LDH, then an exudate is likely.
  • Please refer to UpToDate topic review on evaluation of pleural effusions for more information.
  • LDH: lactate dehydrogenase; LR: likelihood ratio; PFO3: pleural fluid only-3; lab limit: laboratory upper limit of normal reference range for serum LDH; PFL: pleural fluid LDH; ULN: upper limit of normal ; SL: serum LDH.

 
Equations used
 
PFL_to_ULN_SL_ratio = PFL / ULN_SL
Pre-test odds = (Pre-test suspicion of an exudative effusion / 100) / (1 - (Pre-test suspicion of an exudative effusion/100))
Pleural fluid protein LR = e(1.68*(Pleural_fluid_protein-3.263))
Pleural fluid cholesterol LR = e(0.08*(Pleural_fluid_cholesterol-52.208))
LDH_proportion_of_lab_limit_LR = e(4.97*(PFL_to_ULN_SL_ratio-0.676))
Post-test odds = Pre-test odds * Pleural fluid protein LR * Pleural fluid cholesterol LR * LDH_proportion_of_lab_limit_LR
Post-test probability = 100 * Post-test odds / (1 + Post-test odds)

 

 
Only digits 0 to 9 and a single decimal point (".") are acceptable as numeric inputs. Attempted input of other characters into a numeric field may lead to an incorrect result.

Information on this page may not appear correctly if printed.

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