- No symptoms (or minor symptoms)
- High-risk features of proximal extension are absent (refer to the "Factors favoring anticoagulation" column)
- Minor thrombosis in the muscular veins
- A negative D-dimer level (ie, <500 ng/mL)
- Nondiagnostic ultrasonography results
- High risk of or contraindications to bleeding
- Patient preference
| - Symptoms (other than minor ones)
- Thrombus extension into or close to (eg, 1 to 2 cm) the proximal popliteal vein
- Extensive thrombosis involving multiple veins (eg, >5 cm in length, >7 mm in diameter)
- D-dimer ≥500 ng/mL
- Unprovoked DVT
- Persistent/irreversible risk factors, such as active cancer or prolonged immobility
- Previous DVT or pulmonary embolism
- Inpatient status
- COVID-19
- Patient preference
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