- No symptoms (or minor symptoms)
- High-risk features of proximal extension are absent (refer to the "Factors favoring anticoagulation" column)
- Minor thrombosis in the muscular veins
- D-dimer level <500 ng/mL
- High risk of or contraindications to bleeding
- Patient preference
| - Symptoms (other than minor ones)
- Thrombus into or close to the popliteal vein (eg, within 1 to 2 cm) or involving the tibio-peroneal trunk
- Extensive thrombosis involving multiple veins (eg, >5 cm in length, >7 mm in diameter), or bilateral disease
- D-dimer ≥500 ng/mL
- Unprovoked DVT (DVT occurring in the absence of identifiable risk factors)
- Persistent/irreversible risk factors, such as active cancer or prolonged immobility
- Previous DVT or pulmonary embolism
- Inpatient status
- COVID-19, especially severe disease
- Patient preference
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