August 2025
| Opioid | Dose range | Onset and peak of analgesia* | Interval |
| Hydromorphone | 0.2 to 0.5 mg | <5 minutes, peak effect 10 to 20 minutes | Every 5 minutes as needed |
| Morphine | 1 to 3 mg | 5 to 10 minutes; peak effect within 20 minutes | Every 5 to 10 minutes as needed |
| Fentanyl | 25 to 50 mcg | <1 minute, peak effect 2 to 5 minutes | Every 2 to 5 minutes as needed |
| Oliceridine | 1.5 mg initial dose, 0.75 mg subsequent dose¶ | <5 minutes | FDA label limits dosing to no more than hourly |
IV: intravenous; PACU: post anesthesia care unit; FDA: Food and Drug Administration.
* Onset and peak analgesia varies and may be influenced by factors such as dose and co-medications; typical values are provided for purposes of comparison.
¶ After initial two doses, oliceridine dose may be titrated, if needed, based on tolerability and response up to a maximum of 3 mg per dose, at intervals of one hour or more; maximum cumulative dose is 27 mg per day due to risk of QT prolongation.آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
