Statin doses and intensities

	Daily dose range	Low intensity	Moderate intensity	High intensity
Amount of LDL-C lowering		<30%	30 to 49%	≥50%
Lovastatin	20 to 80 mg	20 mg	40 to 80 mg	–
Pravastatin	10 to 80 mg	10 to 20 mg	40 to 80 mg	–
Simvastatin	10 to 40 mg^*	10 mg	20 to 40 mg	–
Fluvastatin	20 to 80 mg	20 to 40 mg	40 mg twice daily (or XL 80 mg once daily)	–
Pitavastatin	1 to 4 mg	–	1 to 4 mg	–
Atorvastatin	10 to 80 mg	–	10 to 20 mg	40 to 80 mg
Rosuvastatin	5 to 40 mg	–	5 to 10 mg	20 to 40 mg

Doses are intended for adult patients with normal organ (ie, kidney, liver) function and are administered once daily, unless otherwise noted.
Coadministration of drugs that alter CYP metabolism or drug transporters (eg, OATP, BCRP) often requires statin dose limitations or avoidance. When initiating or altering drug therapy, use of a drug interactions database, such as the drug interactions program within UpToDate, is advised.

LCL-C: low-density lipoprotein cholesterol; XL: extended-release 24-hour preparation.

* Although simvastatin has been used at higher doses (ie, up to 80 mg/day), we do not recommend doses >40 mg/day as there is a higher risk of myopathy, including rhabdomyolysis.

Data from: Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol 2019; 73:e285.

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Statin doses and intensities