Histologic criteria used in celiac disease

Marsh	IELs Marsh/Corazza	Crypts	Villi	Corazza
Type 0	<40	Normal	Normal
Type 1	>40/>25	Normal	Normal	Grade A
Type 2	>40/>25	Hypertrophic	Normal	Grade A
Type 3	>40/>25	Hypertrophic	Partial to subtotal	Grade B1
Type 3	>40/>25	Hypertrophic	Total	Grade B2
Type 4	<40	Normal	Total

IELs: intraepithelial lymphocytes (per 100 enterocytes).

References:

Corazza GR, Villanacci V, Zambelli C, et al. Comparison of the interobserver reproducibility with different histologic criteria used in celiac disease. Clin Gastroenterol Hepatol 2007; 5:838.
Marsh MN. Gluten, major histocompatibility complex, and the small intestine: A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology 1992; 102:330.

Reproduced with permission from: Rubio-Tapia A, Hill ID, Semrad C, et al. American College of Gastroenterology guidelines update: Diagnosis and management of celiac disease. Am J Gastroenterol 2023; 118(1):59-76. Copyright © 2022 The American College of Gastroenterology. journals.lww.com/ajg/pages/default.aspx.

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Histologic criteria used in celiac disease