Calculator: UCLA Integrated Staging System (UISS) prognostic model for adults with renal cell carcinoma treated with nephrectomy

Input

Disease type	Localized
	Metastatic
Fuhrman nuclear grade
ECOG performance status	0: Fully active; no performance restrictions
	1: Strenuous physical activity restricted; fully ambulatory and able to carry out light work
	2: Capable of all self-care but unable to carry out any work activities; up and about >50% of waking hours
	3: Capable of only limited self-care; confined to bed or chair >50% of waking hours
	4: Completely disabled; cannot carry out any self-care; totally confined to bed or chair
T-Stage	Not applicable to metastatic disease
	T1
	T2
	T3/T4
NM-Stage	Not applicable for localized disease
	N1M0
	N2M0/M1

Important: Inputs must be complete to perform calculation.

UISS interpretation for local disease

T-stage	Fuhrman	ECOG PS	Risk	5-year disease-free survival
T1	1 to 2	0	Low	91.1%
T1	1 to 2	1 to 4	Intermed	80.4%
T1	3 to 4	0 to 4	Intermed	80.4%
T2	1 to 4	0 to 4	Intermed	80.4%
T3	1	0 to 4	Intermed	80.4%
T3	2 to 4	0	Intermed	80.4%
T3	2 to 4	1 to 4	High	54.7%

UISS interpretation for metastatic disease

NM-stage	Fuhrman	ECOG PS	Risk	5-year disease-free survival
N1M0	1 to 4	0 to 4	Low	32%
N2M0/M1	1	0	Low	32%
N2M0/M1	1	1 to 4	Intermed	19.5%
N2M0/M1	2	0	Low	32%
N2M0/M1	2	1 to 4	Intermed	19.5%
N2M0/M1	3	0 to 4	Intermed	19.5%
N2M0/M1	4	0	Intermed	19.5%
N2M0/M1	4	1 to 4	High	<1%

Notes

This model^[1,2] uses the 1997 American Joint Committee on Cancer (AJCC) Tumor (T), Node (N), and Metastatic (M) staging system.^[3] Localized disease is defined as any T and N0 and M0. Metastatic disease is defined as any T and N≥1 and M≥0. For more information regarding contemporary staging systems, please refer to UpToDate discussion of staging of renal cell carcinoma.
This prognostic model has been validated through observational studies; however, it has not been validated in large groups of patients treated with immune checkpoint inhibitors and other targeted agents.
ECOG: Eastern Cooperative Oncology Group; PS: performance status; Intermed: Intermediate.

Only digits 0 to 9 and a single decimal point (".") are acceptable as numeric inputs. Attempted input of other characters into a numeric field may lead to an incorrect result.

Information on this page may not appear correctly if printed.

All information contained in and produced by the EBMcalc system is provided for educational purposes only. This information should not be used for the diagnosis or treatment of any health problem or disease. THIS INFORMATION IS NOT INTENDED TO REPLACE CLINICAL JUDGMENT OR GUIDE INDIVIDUAL PATIENT CARE IN ANY MANNER. Click here for full notice and disclaimer.

Topic 140668 Version 2.0

خرید پکیج

Calculator: UCLA Integrated Staging System (UISS) prognostic model for adults with renal cell carcinoma treated with nephrectomy