Version July 2025
| Clinical syndrome | Incidence*[1] |
| Bacteremic pneumonia (with or without empyema) | 116 |
| Bacteremia of unknown source | 7 |
| Meningitis | 5 |
| Spontaneous bacterial peritonitis | 5 |
| Septic arthritis | 2 |
| Endocarditis | 2 |
| Spinal epidural abscess | 1 |
| Osteomyelitis | 1 |
| Dental abscess | 1 |
IPD: invasive pneumococcal disease.
* Areas of involvement in 136 patients with IPD at a Veterans Affairs Medical Center in the United States from 2000 to 2009. Number of sites involved exceeds the number of patients because several patients had more than one site involved.