Types of renal amyloidosis

	Amyloid type	Amyloid parent protein	Kidney involvement
	Amyloid type	Amyloid parent protein	Glomerular	Tubulointerstitial	Vascular
Acquired	AL/AH/AHL	Immunoglobulin light or heavy chain	X	X	X
	AA	Serum amyloid A	X	X	X
	AApoAIV	Apolipoprotein AIV		X^*
Hereditary	AA	Serum amyloid A	X	X	X
	AApoAI	Apolipoprotein AI		X^*
	AApoAII	Apolipoprotein AII	X
	AApoAIV	Apolipoprotein AIV		X^*
	AApoCII	Apolipoprotein CII	X	X^*
	AApoCIII	Apolipoprotein CIII	X	X	X
	AFib	Fibrinogen A alpha	X
	AGel	Gelsolin	X
	ALys	Lysozyme	X	X^*
	ATTR	Transthyretin (mutant type)	X	X	X
Unknown	ALECT2	Leukocyte chemotactic factor 2	X^¶	X	X

* Medullary tubulointerstitium.

¶ Less common.

Adapted from: Gurung R, Li T. Renal Amyloidosis: Presentation, Diagnosis, and Management. Am J Med 2022; 135 Suppl 1:S38.

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