Comparison of products containing fibrinogen

	Cryoprecipitate*	Fibrinogen concentrate
Constituents	Fibrinogen Factor VIII Factor XIII von Willebrand factor Fibronectin	Fibrinogen
Efficacy for fibrinogen replacement	Similar	Similar
Volume	50 to 200 mL (5 to 10 units) for at least 750 mg to 1500 mg of fibrinogen	50 mL for 900 mg to 1300 mg of fibrinogen^¶
Dosing^Δ	Generally 5 to 10 units (1 to 2 pools); each pool contains approximately 5 units	Generally 1 to 2 vials (900 to 1300 mg fibrinogen per vial)
Other aspects of administration	Requires thawing	Requires reconstitution
Adverse events	Thromboembolic events Allergic reactions Volume overload Infection – Each unit approximately equivalent to 1 unit of RBCs	Thromboembolic events Allergic reactions

Fibrinogen concentrate is probably more expensive than Cryoprecipitate in many settings; however, cost differences are highly variable and depend on whether only the cost of the product versus total costs of care are incorporated.

RBC: red blood cell; HIV: human immunodeficiency virus.

* Pathogen-reduced Cryoprecipitate contains the same components and has the same properties as Cryoprecipitate that has not been pathogen-reduced; the major difference is higher cost and lower risk of transfusion-transmitted infections such as HIV and hepatitis C virus (HCV) due to the processing steps that inactivate viruses and other microorganisms.

¶ The amount of fibrinogen per vial varies by product; refer to product labeling.

Δ Refer to UpToDate topic on Cryoprecipitate and fibrinogen concentrate for review of dose estimation and calculation.

Graphic 141747 Version 1.0

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Comparison of products containing fibrinogen