Diagnostic framework for pediatric joint hypermobility

	Generalized joint hypermobility	Skin and tissue abnormalities	Musculoskeletal complications	Core comorbidities
Asymptomatic
Pediatric generalized joint hypermobility	Present	Absent	Absent	Absent
Pediatric generalized joint hypermobility with skin involvement	Present	Present	Absent	Absent
Symptomatic conditions
Pediatric generalized joint hypermobility with core comorbidities	Present	Absent	Absent	Present
Pediatric generalized joint hypermobility with core comorbidities and with skin involvement	Present	Present	Absent	Present
Pediatric hypermobility spectrum disorder, musculoskeletal subtype	Present	Absent	Present	Absent
Pediatric hypermobility spectrum disorder, musculoskeletal subtype with skin involvement	Present	Present	Present	Absent
Pediatric hypermobility spectrum disorder, systemic subtype	Present	Absent	Present	Present
Pediatric hypermobility spectrum disorder, systemic subtype with skin involvement	Present	Present	Present	Present

This table shows the distribution of the different clinical features within each diagnostic group based on the presence or absence of skin pathology, musculoskeletal complications, and comorbidities.

From: Tofts LJ, Simmonds J, Schwartz SB, et al. Pediatric joint hypermobility: A diagnostic framework and narrative review. Orphanet J Rare Dis 2023; 18:104. Copyright © 2023 The Authors. https://ojrd.biomedcentral.com/articles/10.1186/s13023-023-02717-2 (Accessed on September 14, 2023). Reproduced under the terms of the Creative Commons Attribution License 4.0.

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Diagnostic framework for pediatric joint hypermobility