Systemic involvement of disorders that cause muscle weakness

System	Manifestation	Causes
Brain	Seizures, cognitive disorder, abnormal brain imaging	Congenital myopathy, mitochondrial disorder, myotonic dystrophy
Eye	Cataracts, retinitis pigmentosa	Myotonic dystrophy, mitochondrial disorder
Skin	Follicular hyperkeratosis or keloids	Col6A-related congenital muscular dystrophy
Skin	Gottron papules, heliotropic rash, mechanic's hands, facial erythema, calcinosis	Inflammatory myopathy
Cardiac	Cardiac conduction defects or cardiomyopathies	Amyloid myopathy, myotonic and other dystrophies
Pulmonary	Involvement of respiratory muscles causing orthopnea and dyspnea on exertion	Muscular dystrophies
Pulmonary	Interstitial lung disease	Inflammatory myopathies

Courtesy of Erik Ortega, MD.

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