Drugs and toxins that can cause hypophosphatemia

Acetazolamide

Antacids (aluminum- and magnesium-based)

Antiretroviral agents:

Bisphosphonates

Chemotherapeutic agents:

Chimeric antigen receptor modified (CAR)-T cell therapy (eg, tisagenlecleucel, axicabtagene ciloleucel)
Cisplatin
Ifosfamide
Tyrosine kinase inhibitors (eg, imatinib)
Vascular endothelial growth factor (VEGF) inhibitors (eg, sorafenib)

Denosumab

Heavy metals (cadmium, lead, arsenic)

Insulin

Intravenous iron (specifically, ferric carboxymaltose)

Mechanistic (mammalian) target of rapamycin (mTOR) inhibitors (eg, temsirolimus)

Niacin

Phosphate binders

Valproate

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