Category | Commonly used definition |
Classic FUO | Temperature >38.3°C (100.9°F) recorded on several occasions for >3 weeks, despite 3 outpatient clinic evaluations, 1 week of intensive outpatient investigation, or 3 days of hospital-based evaluation.* |
Health care-associated FUO | |
| Temperature >38.3°C (100.9°F) recorded on several occasions in an ICU patient despite ≥3 days of investigations. Fever must not have been present or incubating on admission. |
| Same definition as for ICU patient, except patient is hospitalized but not critically ill. |
| Same definition as for ICU patient, except fever is usually defined as ≥38.0°C (100.4°F). |
FUO in immunocompromised patients¶ | |
| Temperature ≥38.3°C (100.9°F) or ≥38.0°C (100.4°F) sustained over a one-hour period, recorded on several occasions over at least 3 days, despite appropriate antimicrobial therapy. Neutropenia is defined as <500 neutrophils/microL or impending fall to that level within 48 hours. |
| Temperature ≥38.3°C (100.9°F) recorded on several occasions for >3 weeks for outpatient or >3 days for inpatient despite appropriate evaluation. |
Travel-associated FUO | Temperature >38.3°C (100.9°F) recorded on several occasions for >3 weeks, despite 3 outpatient clinic evaluations, 1 week of intensive outpatient investigation, or 3 days of hospital-based evaluation, in a patient who travelled to another country, typically within the prior 12 months. |
FUO: fever of unknown origin.
* Because peak normal temperature in well individuals is 38.0°C, some experts have proposed a cut-off temperature for classic FUO of >38.0°C (100.4°F) instead of >38.3°C (100.9°F).[1]
¶ Formal definitions for FUO have not been defined for immunocompromising conditions other than neutropenia and HIV.Adapted from:
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