This figure summarizes an approach to evaluating for fibrosis in patients with MASLD. This algorithm is intended for use in conjunction with UpToDate content on the clinical features and diagnosis of MASLD. We use ultrasound-based elastography to evaluate for advanced fibrosis or cirrhosis. If imaging methods are not available, alternatives include serologic tests. Refer to UpToDate content on noninvasive assessment of hepatic fibrosis for details.
Further management of patients with cirrhosis includes screening for and preventing cirrhosis-related complications (eg, variceal bleeding, hepatocellular carcinoma).MASLD: metabolic dysfunction-associated steatotic liver disease.
* Liver biopsy provides information on grading of necroinflammatory activity in addition to staging severity of fibrosis.