Version July 2025
| Parameter | Chronic uveitis | Acute flare of uveitis |
| Initial dose | Typically 40 to 60 mg/day of prednisone or its equivalent (maximum 80 mg/day) | Typically 40 to 60 mg/day of prednisone or its equivalent (maximum 80 mg/day) |
| Tapering schedule for prednisone or equivalent* | ||
| Decrease by 10 mg/day every 1 to 2 weeks | Decrease by 10 mg/day every 1 to 2 days |
| Decrease by 5 mg/day every 1 to 2 weeks | Decrease by 5 mg/day every 1 to 2 days |
| Decrease by 2.5 mg/day every 1 to 2 weeks | Decrease by 2.5 mg/day every 1 to 2 days |
| Decrease by 1 to 2.5 mg/day every 1 to 4 weeks until the patient is off or to the lowest dose that controls inflammation¶ | Decrease by 1 to 2.5 mg/day every 1 to 4 days until the patient is off or to the lowest dose that controls inflammation¶ |
* Tapering should only start once patients are in remission, which typically occurs within 1 month of initial high-dose therapy. Dose and tapering are adjusted based on the degree of inflammation, associated symptoms, and the tolerance of and response to treatment.
¶ Patients may require the addition of glucocorticoid-sparing immunosuppressive therapy if they are unable to taper off of glucocorticoids. Refer to UpToDate content on the treatment of uveitis for specific indications.