Clean the skin where you plan to give the shot with an alcohol wipe. Let it dry.
For some medicines, pinch the skin where the medicine is injected. To do this, pinch 1 to 2 inches (2.5 to 5 cm) of skin between your fingers and thumb on 1 hand. For others, stretch the skin between your fingers.
With your other hand, place the needle guard at end of the autoinjector against the skin. For some autoinjectors, this starts the injection. For others, use your thumb to press a button to start the injection. Press the button all of the way down until it stops. Keep pressing the autoinjector into the skin for as long as it says in the instructions for your device, usually 5 to 15 seconds.
Let go of the skin, and pull the autoinjector straight away from the skin. The needle guard will cover the needle. If you see blood or clear fluid when you remove the needle, press the area for about 5 seconds. Do not rub.